UniProt Accession

 RSC58_YEAST; Q07979; D6VY35 

Genbank Protein ID

 Z73205; BK006945 

Genbank Nucleotide ID

 CAA97557.1; DAA09351.1 

Protein Name

 Chromatin structure-remodeling complex protein RSC58 

Protein Synonyms/Alias

 Remodel the structure of chromatin complex subunit 58 

Gene Name

 RSC58 

Gene Synonyms/Alias

 YLR033W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
154	NIKSRSGKLLSGNEM	acetylation	[1]
322	GYMDLYEKNEKKVKQ	sumoylation	[2]
328	EKNEKKVKQEELLNT	sumoylation	[2]
437	RKERILNKVLKPTTE	ubiquitination	[3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification of sumoylated proteins by systematic immunoprecipitation of the budding yeast proteome.
 Wykoff DD, O'Shea EK.
 Mol Cell Proteomics. 2005 Jan;4(1):73-83. [PMID: 15596868]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. 

Sequence Annotation

  

Keyword

 Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 502 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:UniProtKB.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

 IPR001487; Bromodomain. 

Pfam

 PF00439; Bromodomain 

SMART

  

PROSITE

  

PRINTS