CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Claudin 8 
Protein Synonyms/Alias
  
Gene Name
 Cldn8 
Gene Synonyms/Alias
 mCG_128977 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
221RSPSIYSKSQYV***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Membrane; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MATYALQMAA LVLGGVGMVG TVAVTIMPQW RVSAFIESNI VVFENRWEGL WMNCMRHANI 60
RMQCKVYDSL LALSPDLQAS RGLMCAASVL AFLAFMTAIL GMKCTRCTGD DENVKSRILL 120
TAGIIFFITG LVVLIPVSWV ANSIIRDFYN PLVDVALKRE LGEALYIGWT TALVLIAGGA 180
LFCCVFCCTE RSNSYRYSVP SHRTTQRSFH AEKRSPSIYS KSQYV 225 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR006187; Claudin.
 IPR003926; Claudin8.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 
Pfam
 PF00822; PMP22_Claudin 
SMART
  
PROSITE
 PS01346; CLAUDIN 
PRINTS
 PR01077; CLAUDIN.
 PR01446; CLAUDIN8.