UniProt Accession

 PEA15_RAT; Q5U318; Q78ZC9 

Genbank Protein ID

 AJ243949; BC085766 

Genbank Nucleotide ID

 CAB51573.1; AAH85766.1 

Protein Name

 Astrocytic phosphoprotein PEA-15 

Protein Synonyms/Alias

 15 kDa phosphoprotein enriched in astrocytes 

Gene Name

 Pea15 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
98	EEDELDTKLTRIPSA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). 

Sequence Annotation

 DOMAIN 3 81 DED.
 REGION 98 107 Microtubule-binding (Potential).
 REGION 122 129 Microtubule-binding (Potential).
 MOD_RES 61 61 Phosphoserine (By similarity).
 MOD_RES 104 104 Phosphoserine; by PKC (By similarity).
 MOD_RES 116 116 Phosphoserine; alternate.
 MOD_RES 116 116 Phosphoserine; by CaMK2; alternate (By  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Sugar transport; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0046325; P:negative regulation of glucose import; IEA:Compara.
 GO:0043278; P:response to morphine; IEP:RGD. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS