UniProt Accession

 ETS2_HUMAN; P15036; A6NM68; D3DSH6; Q53Y89 

Genbank Protein ID

 J04102; AF017257; AK315563; BT006838; AL163278; AP001732; AP001040; CH471079; CH471079; CH471079; BC017040; BC042954; X55181; M11922 

Genbank Nucleotide ID

 AAA52412.1; AAB94057.1; BAG37939.1; AAP35484.1; CAB90468.1; BAA95514.1; EAX09673.1; EAX09674.1; EAX09676.1; AAH17040.1; AAH42954.1; CAA38966.1; AAA52411.1 

Protein Name

 Protein C-ets-2 

Protein Synonyms/Alias

  

Gene Name

 ETS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MNDFGIKNMDQVAP	ubiquitination	[1]
92	ATFSGFKKEQRRLGI	ubiquitination	[1]
144	QMLCNLGKERFLELA	ubiquitination	[1, 2]
241	QEFQMFPKSRLSSVS	ubiquitination	[1]
326	SQSLCLNKPTMSFKD	ubiquitination	[1, 3]
332	NKPTMSFKDYIQERS	ubiquitination	[3]
427	GLRYYYDKNIIHKTS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. 

Sequence Annotation

 DOMAIN 85 170 PNT.
 DNA_BIND 363 443 ETS.
 MOD_RES 295 295 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR016311; Transform_prot_C-ets.
 IPR027276; Transform_prot_C-ets-2.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF02198; SAM_PNT 

SMART

 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.