| Tag | Content |
|---|
| CPLM ID | CPLM-034647 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 3 subunit M |
Protein Synonyms/Alias | eIF3m |
Gene Name | Eif3m |
Gene Synonyms/Alias | RGD1565840_predicted; rCG_27120 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 213 | RCIVRALKDPNAFLF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). |
Sequence Annotation | DOMAIN 237 335 PCI (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 374 AA |
Protein Sequence | MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV 60
ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKNTPVR 120
YTVYCSLIKV AASCGAIQYI PTELDQVRKW ISDWKLTTEK KHTLLRLLYE ALVDCKKSDA 180
ASKVMVELLG SYTEDNASQA RVDAHRCIVR ALKDPNAFLF DHLLTLKPVK FLEGELIHDL 240
LTIFVSAKLA SYVKFYQNNK DFIDSLGLLH EQNMAKMRLL TFMGMAVENK EISFDTMQQE 300
LQIGADDVEA FVIDAVRTKM VYCKIDQTQR KVVVSHSTHR TFGKQQWQQL YDTLNAWKQN 360
LNKVKNSLLS LSDT 374 |
Gene Ontology | GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP. GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP. GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:HAMAP. GO:0003743; F:translation initiation factor activity; IEA:HAMAP. GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP. GO:0006446; P:regulation of translational initiation; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |