UniProt Accession

 H0VCH1_CAVPO; H0VCH1 

Genbank Protein ID

 AAKN02016025 

Genbank Nucleotide ID

  

Protein Name

 Isocitrate dehydrogenase [NADP] 

Protein Synonyms/Alias

  

Gene Name

 LOC100726681 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Cavia porcellus (Guinea pig) 

NCBI Taxa ID

 10141 

Lysine Modification

Position	Peptide	Type	References
48	DKRIKVAKPVVEMDG	acetylation	[1]
67	RIIWQFIKEKLILPH	acetylation	[1]
80	PHVDVQLKYFDLGLP	acetylation	[1]
106	DSALATQKYSVAVKC	acetylation	[1]
133	FKLKKMWKSPNGTIR	acetylation	[1]
155	FREPIICKNIPRLVP	acetylation	[1]
166	RLVPGWTKPITIGRH	acetylation	[1]
180	HAHGDQYKATDFVVD	acetylation	[1]
199	FRMVFTPKDGSGPKE	acetylation	[1]
205	PKDGSGPKEWEVYNF	acetylation	[1]
243	FQYAIQKKWPLYMST	acetylation	[1]
256	STKNTILKAYDGRFK	acetylation	[1]
263	KAYDGRFKDIFQEIF	acetylation	[1]
272	IFQEIFDKHYKTDFD	acetylation	[1]
275	EIFDKHYKTDFDKHK	acetylation	[1]
280	HYKTDFDKHKIWYEH	acetylation	[1]
282	KTDFDKHKIWYEHRL	acetylation	[1]
299	DMVAQVLKSSGGFVW	acetylation	[1]
384	RGLEHRGKLDGNQDL	acetylation	[1]
400	RFAQTLEKVCVETVE	acetylation	[1]
413	VESGAMTKDLAGCIH	acetylation	[1]
442	TDFLDTIKSNLDKAL	acetylation	[1]
447	TIKSNLDKALGKQ**	acetylation	[1]

Reference

 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 

Functional Description

  

Sequence Annotation

 NP_BIND 115 117 NADP (By similarity).
 NP_BIND 349 354 NADP (By similarity).
 REGION 134 140 Substrate binding (By similarity).
 METAL 291 291 Magnesium or manganese (By similarity).
 METAL 314 314 Magnesium or manganese (By similarity).
 BINDING 117 117 Substrate (By similarity).
 BINDING 122 122 NADP (By similarity).
 BINDING 149 149 Substrate (By similarity).
 BINDING 172 172 Substrate (By similarity).
 BINDING 299 299 NADP (By similarity).
 BINDING 367 367 NADP; via amide nitrogen and carbonyl  

Keyword

 Complete proteome; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS