CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Condensin-2 complex subunit G2 
Protein Synonyms/Alias
  
Gene Name
 NCAPG2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
109LSYFHHQKKVRQGVEubiquitination[1]
110SYFHHQKKVRQGVEEubiquitination[1, 2]
124EMLYRLYKPILWRGLubiquitination[1, 3, 4, 5]
194TGILGVCKITSKYWEubiquitination[1, 2]
198GVCKITSKYWEMMPPubiquitination[1]
214ILIDLLKKVTGELAFubiquitination[1, 4]
234DVRCSVFKCLPMILDubiquitination[1, 2]
243LPMILDNKLSHPLLEubiquitination[1]
266SLHDNSEKVRVAFVDubiquitination[1, 2, 4, 5]
277AFVDMLLKIKAVRAAubiquitination[1]
288VRAAKFWKICPMEHIubiquitination[1]
361TACTNIAKLIHVIRHubiquitination[1]
393EEEDGREKENVTVLDubiquitination[4]
433DRSMENNKEAKLYTIubiquitination[4]
436MENNKEAKLYTINKFubiquitination[1]
442AKLYTINKFASVLPEubiquitination[1, 2, 3, 4, 5, 6, 7]
452SVLPEYLKVFKDDRCubiquitination[1, 2, 3, 4, 5]
576LLSAPRKKLNHLLKAubiquitination[1]
582KKLNHLLKALETSKAubiquitination[1, 2]
588LKALETSKADLESLLubiquitination[1, 2, 4, 5, 6, 7]
601LLQTPGGKPRGFSEAubiquitination[1, 2, 4, 6, 7]
663DQEEDYLKLHRVIYQubiquitination[1, 4]
732TGSSLIQKTDSDEEVubiquitination[4]
748MLLDTVQKVFQKMLEubiquitination[7]
752TVQKVFQKMLECIARubiquitination[1]
763CIARSFRKQPEEGLRubiquitination[1]
799CLIGIIIKSSNVVRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 888 AA 
Protein Sequence
MLLECFININ YIKKEEGRRF LSCLFNWNIN FIKMIHGTIK NQLQGLQKSL MVYIAEIYFR 60
AWKKASGKIL EAIENDCIQD FMFHGIHLPR RSPVHSKVRE VLSYFHHQKK VRQGVEEMLY 120
RLYKPILWRG LKARNSEVRS NAALLFVEAF PIRDPNLHAI EMDSEIQKQF EELYSLLEDP 180
YPMVRSTGIL GVCKITSKYW EMMPPTILID LLKKVTGELA FDTSSADVRC SVFKCLPMIL 240
DNKLSHPLLE QLLPALRYSL HDNSEKVRVA FVDMLLKIKA VRAAKFWKIC PMEHILVRLE 300
TDSRPVSRRL VSLIFNSFLP VNQPEEVWCE RCVTLVQMNH AAARRFYQYA HEHTACTNIA 360
KLIHVIRHCL NACIQRAVRE PPEDEEEEDG REKENVTVLD KTLSVNDVAC MAGLLEIIVI 420
LWKSIDRSME NNKEAKLYTI NKFASVLPEY LKVFKDDRCK IPLFMLMSFM PASAVPPFSC 480
GVISTLRSRE EGAVDKSYCT LLDCLCSWGQ VGHILELVDN WLPTEHAQAK SNTASKGRVQ 540
IHDTRPVKPE LALVYIEYLL THPKNRECLL SAPRKKLNHL LKALETSKAD LESLLQTPGG 600
KPRGFSEAAA PRAFGLHCRL SIHLQHKFCS EGKVYLSMLE DTGFWLESKI LSFIQDQEED 660
YLKLHRVIYQ QIIQTYLTVC KDVVMVGLGD HQFQMQLLQR SLGIMQTVKG FFYVSLLLDI 720
LKEITGSSLI QKTDSDEEVA MLLDTVQKVF QKMLECIARS FRKQPEEGLR VSDVEELTPP 780
EHLSDLPPFS RCLIGIIIKS SNVVRSFLDE LKACVASNDI EGIVCLTAAV HIILVINAGK 840
HKSSKVREVA ATVHRKLKTF MEITLEEDSI ERFLYESSSR TLGELLNS 888 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR024741; Condensin2_G2. 
Pfam
 PF12422; Condensin2nSMC 
SMART
  
PROSITE
  
PRINTS