CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000906
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal-induced proliferation-associated 1-like protein 3 
Protein Synonyms/Alias
 SIPA1-like protein 3; SPA-1-like protein 3 
Gene Name
 SIPA1L3 
Gene Synonyms/Alias
 KIAA0545; SPAL3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
799FRDFLLAKVINAENAubiquitination[1]
1448VPKSFFSKQPVRNKHacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 DOMAIN 611 828 Rap-GAP.
 DOMAIN 966 1042 PDZ.
 MOD_RES 1448 1448 N6-acetyllysine.
 MOD_RES 1544 1544 Phosphoserine.
 MOD_RES 1699 1699 Phosphothreonine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1781 AA 
Protein Sequence
MTTYRAIPSD GVDLAASCGA RVGDVLPGPH TGDYAPLGFW AQNGSMSQPL GESPATATAT 60
ATATTRPSPT TPAMPKMGVR ARVADWPPKR EALREHSNPS PSQDTDGTKA TKMAHSMRSI 120
QNGQPPTSTP ASSGSKAFHR LSRRRSKDVE FQDGWPRSPG RAFLPLRHRS SSEITLSECD 180
AEDAGEPRGA RHTGALPLFR EYGSTSSIDV QGMPEQSFFD ILNEFRSEQP DARGCQALTE 240
LLRADPGPHL MGGGGGAKGD SHNGQPAKDS LLPLQPTKEK EKARKKPARG LGGGDTVDSS 300
IFRKLRSSKP EGEAGRSPGE ADEGRSPPEA SRPWVCQKSF AHFDVQSMLF DLNEAAANRV 360
SVSQRRNTTT GASAASAASA MASLTASRAH SLGGLDPAFT STEDLNCKEN LEQDLGDDNS 420
NDLLLSCPHF RNEIGGECER NVSFSRASVG SPSSGEGHLA EPALSAYRTN ASISVLEVPK 480
EQQRTQSRPR QYSIEHVDLG ARYYQDYFVG KEHANYFGVD EKLGPVAVSI KREKLEDHKE 540
HGPQYQYRII FRTRELITLR GSILEDATPT ATKHGTGRGL PLKDALEYVI PELNIHCLRL 600
ALNTPKVTEQ LLKLDEQGLC RKHKVGILYC KAGQSSEEEM YNNEEAGPAF EEFLSLIGEK 660
VCLKGFTKYA AQLDVKTDST GTHSLYTMYQ DYEIMFHVST LLPYTPNNRQ QLLRKRHIGN 720
DIVTIIFQEP GALPFTPKNI RSHFQHVFII VRVHNPCTDN VCYSMAVTRS KDAPPFGPPI 780
PSGTTFRKSD VFRDFLLAKV INAENAAHKS DKFHTMATRT RQEYLKDLAE NCVSNTPIDS 840
TGKFNLISLT SKKKEKTKAR AGAEQHSAGA IAWRVVAQDY AQGVEIDCIL GISNEFVVLL 900
DLRTKEVVFN CYCGDVIGWT PDSSTLKIFY GRGDHIFLQA TEGSVEDIRE IVQRLKVMTS 960
GWETVDMTLR RNGLGQLGFH VKYDGTVAEV EDYGFAWQAG LRQGSRLVEI CKVAVVTLTH 1020
DQMIDLLRTS VTVKVVIIPP FEDGTPRRGW PETYDMNTSE PKTEQESITP GGRPPYRSNA 1080
PWQWSGPASH NSLPASKWAT PTTPGHAQSL SRPLKQTPIV PFRESQPLHS KRPVSFPETP 1140
YTVSPAGADR VPPYRQPSGS FSTPGSATYV RYKPSPERYT AAPHPLLSLD PHFSHDGTSS 1200
GDSSSGGLTS QESTMERQKP EPLWHVPAQA RLSAIAGSSG NKHPSRQDAA GKDSPNRHSK 1260
GEPQYSSHSS SNTLSSNASS SHSDDRWFDP LDPLEPEQDP LSKGGSSDSG IDTTLYTSSP 1320
SCMSLAKAPR PAKPHKPPGS MGLCGGGREA AGRSHHADRR REVSPAPAVA GQSKGYRPKL 1380
YSSGSSTPTG LAGGSRDPPR QPSDMGSRVG YPAQVYKTAS AETPRPSQLA QPSPFQLSAS 1440
VPKSFFSKQP VRNKHPTGWK RTEEPPPRPL PFSDPKKQVD TNTKNVFGQP RLRASLRDLR 1500
SPRKNYKSTI EDDLKKLIIM DNLGPEQERD TGQSPQKGLQ RTLSDESLCS GRREPSFASP 1560
AGLEPGLPSD VLFTSTCAFP SSTLPARRQH QHPHPPVGPG ATPAAGSGFP EKKSTISASE 1620
LSLADGRDRP LRRLDPGLMP LPDTAAGLEW SSLVNAAKAY EVQRAVSLFS LNDPALSPDI 1680
PPAHSPVHSH LSLERGPPTP RTTPTMSEEP PLDLTGKVYQ LEVMLKQLHT DLQKEKQDKV 1740
VLQSEVASLR QNNQRLQEES QAASEQLRKF AEIFCREKKE L 1781 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR021818; DUF3401.
 IPR001478; PDZ.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF11881; DUF3401
 PF02145; Rap_GAP 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ
 PS50085; RAPGAP 
PRINTS