UniProt Accession

 RAB14_MOUSE; Q91V41 

Genbank Protein ID

 AK002704; BC009085; BC025139; BC056648 

Genbank Nucleotide ID

 BAB22298.1; AAH09085.1; AAH25139.1; AAH56648.1 

Protein Name

 Ras-related protein Rab-14 

Protein Synonyms/Alias

  

Gene Name

 Rab14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
170	DAFLEAAKKIYQNIQ	ubiquitination	[1]
171	AFLEAAKKIYQNIQD	ubiquitination	[1]
193	AESGVQHKPSAPQGG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). 

Sequence Annotation

 NP_BIND 18 26 GTP (By similarity).
 NP_BIND 66 70 GTP (By similarity).
 NP_BIND 124 127 GTP (By similarity).
 NP_BIND 154 156 GTP (By similarity).
 MOTIF 40 48 Effector region (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 98 98 Phosphothreonine.
 MOD_RES 99 99 Phosphotyrosine.
 MOD_RES 215 215 Cysteine methyl ester (By similarity).
 LIPID 213 213 S-geranylgeranyl cysteine (By
 LIPID 215 215 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0009790; P:embryo development; IMP:UniProtKB.
 GO:0032456; P:endocytic recycling; ISS:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0006895; P:Golgi to endosome transport; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.