| Tag | Content |
|---|
| CPLM ID | CPLM-014643 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
Protein Synonyms/Alias | SERCA3; SR Ca(2+)-ATPase 3; Calcium pump 3 |
Gene Name | Atp2a3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | VEVAVGDKVPADLRL | ubiquitination | [1] | | 713 | NDAPALKKAEIGIAM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. |
Sequence Annotation | ACT_SITE 351 351 4-aspartylphosphate intermediate (By
METAL 304 304 Calcium 2; via carbonyl oxygen (By
METAL 305 305 Calcium 2; via carbonyl oxygen (By
METAL 307 307 Calcium 2; via carbonyl oxygen (By
METAL 309 309 Calcium 2 (By similarity).
METAL 703 703 Magnesium (By similarity).
METAL 707 707 Magnesium (By similarity).
METAL 768 768 Calcium 1 (By similarity).
METAL 771 771 Calcium 1 (By similarity).
METAL 796 796 Calcium 2 (By similarity).
METAL 799 799 Calcium 1 (By similarity).
METAL 800 800 Calcium 1 (By similarity).
METAL 800 800 Calcium 2 (By similarity).
METAL 908 908 Calcium 1 (By similarity).
BINDING 515 515 ATP (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 662 662 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1038 AA |
Protein Sequence | MEEAHLLSAA DVLRRFSVTA EGGLSLEQVT DARERYGPNE LPTEEGKSLW ELVVEQFEDL 60
LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 120
EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 180
TGESVSVTKH TDAIPDPRAV NQDKKNMLFS GTNIASGKAL GVAVATGLQT ELGKIRSQMA 240
AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 300
ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
MSVCRMFVVA EAEAGTCRLH EFTISGTTYT PEGEVRQGEQ PVRCGQFDGL VELATICALC 420
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLK GLSRVERAGA CNSVIKQLMR 480
KEFTLEFSRD RKSMSVYCTP TRADPKVQGS KMFVKGAPES VIERCSSVRV GSRTAPLSTT 540
SREHILAKIR DWGSGSDTLR CLALATRDTP PRKEDMHLDD CSRFVQYETD LTFVGCVGML 600
DPPRPEVAAC ITRCSRAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVLG KAYTGREFDD 660
LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 720
GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAI 780
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKP PRNPREALIS GWLFFRYLAI 840
GVYVGLATVA AATWWFLYDT EGPQVTFYQL RNFLKCSEDN PLFAGIDCKV FESRFPTTMA 900
LSVLVTIEMC NALNSVSENQ SLLRMPPWLN PWLLGAVVMS MALHFLILLV PPLPLIFQVT 960
PLSGRQWGVV LQMSLPVILL DEALKYLSRN HMDGVLGTFM QARSRQLPTT SRTPYHTGKK 1020
GPEVNPGSRG ESPVWPSD 1038 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005388; F:calcium-transporting ATPase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |