CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036479
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase WNK2 
Protein Synonyms/Alias
  
Gene Name
 Wnk2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
349DLGLATLKRASFAKSacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2137 AA 
Protein Sequence
MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 60
ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 120
TQEPSPDPTT ASAAAAQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 180
DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 240
EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 300
WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 360
PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 420
VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 480
EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 540
WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 600
PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 660
GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 720
PSQPAPPVQQ VLAPQPMGTV QPVPSHLPPY LAPTSQVVAP AQLKPLQMPQ PPLQPLAQVP 780
PQMPQMPVVP PITPLTGLDG LPQTLTDLPA ANVAPVPPPQ YFSPAVILPS LTTPLPTSPA 840
LPMQAVKLPH PPGTPLAVPC QTIVPNAPAA IPLLAVAPQG VAALSIHPAV AQIPAQPVYP 900
AAFPQMVPGD IPPSPHHTVQ SLRATPPQLA SPVPPQPVQP SVIHLPEQAA PTAASGTQVL 960
LGHPPSYTAD VAAPVSAVSL PPAVLSPPLP DTLLPTVPDL LPKVPSSLAP TVVAASQSAP 1020
AQTSSLLLPT NPPLPTGPAV AGPCPAVQLM VEVAQEEQVS QDKPPGPPQS SESFGGSDVT 1080
SGRDLSDSCE GTFGGGRLEG RTARKHHRRS TRARSRQERA SRPRLTILNV CNTGDKMVEC 1140
QLETHNHKMV TFKFDLDGDA PDEIATYMVE HDFILPAERE TFIEQMKDVM DKAEDMLSED 1200
TDADHGSDTG TSPPHLGTCG LATGEENRQS QANAPVYQQN VLHTGKRWFI ICPVAEHPAT 1260
DTSESSPPLP LSSLQPEASQ DPAPYPDQLS LTDKPSFPAA QQLLSQAGSS NPPGGASAPL 1320
APSSPPVTTV IPAAPATSTV PESAAGTAMQ AGGPGTHQGP ASVHETLQPL AETRSAQCTA 1380
QPLSTGQGPC TPALEASRCS TGLGEPISTR EVSTQGEPLP ASVPEPSPPT GATQSVPGQP 1440
PPPLPITVGA ISLAAPQLPS PPLGPTAPPP PPSALESDGE GPPPRVGFVD NTIKSLDEKL 1500
RTLLYQEHVP TSSASAGTPM EASDRDFTLE PLRGDLPSAL SDKTPSLTQQ TQPSLEKSET 1560
APAGWALAQR EQGASSPMTA ESSSSNTLGC DSDAGQVASD SSTAPSVPQD ASGSSVPTHM 1620
DPKDQNSSVP REALAAPMQS GPGSFTVGSP AQLRGARDSG SPHKRPGQQD NSSPAKTVGR 1680
FSVVSTQDEW TLASPHSLRY SAPPDVYLDE IPSSPEVKLA VRRVQTASSI EVGVEEPASS 1740
DSGDERPRRR SQVQKQSSLP GTGGVASDFV KKATAFLHRS SRAGSLGPET PSRAGVKVPT 1800
ISITSFHSQS SYISSDNDSE FEDADIKKEL RSLREKHLKE ISELQSQQKQ EIEALYRRLG 1860
KPLPPNVGFF HTAPPMGRRR KTSKSKLKAG KLLNPLVQQL KVVASSTGHL SDSSRGPPTK 1920
DPAHASTPPG TKAVQTQQPC SVRASLSTDI CSGLASDGGG ARGQGWTVYH PTSERGAYKS 1980
SSKPRARFLS GPVSVSIWSA LKRLCLGKEH SSRSSTSSLA PGPEPGPQPT LHVQAQVNNS 2040
NNKKGTFTDD LHKLVDEWTT KTVGAAQVKP TLNQLKQTQK LHDMEASGDA RATSVPRAAV 2100
GASCLAPAPG PLSTTATPGA TPALPVPIPD PESEKPD 2137 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR024678; Kinase_OSR1/WNK_CCT.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF12202; OSR1_C
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS