UniProt Accession

 G3V5Z7_HUMAN; G3V5Z7 

Genbank Protein ID

 AL121594; AL133163 

Genbank Nucleotide ID

  

Protein Name

 Proteasome subunit alpha type 

Protein Synonyms/Alias

  

Gene Name

 PSMA6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	YQVEYAFKAINQGGL	ubiquitination	[1]
45	TSVAVRGKDCAVIVT	ubiquitination	[1]
54	CAVIVTQKKVPDKLL	ubiquitination	[1]
55	AVIVTQKKVPDKLLD	ubiquitination	[1]
59	TQKKVPDKLLDSSTV	ubiquitination	[1]
71	STVTHLFKITENIGC	ubiquitination	[1]
102	RYEAANWKYKYGYEI	ubiquitination	[1, 2]
104	EAANWKYKYGYEIPV	ubiquitination	[1]
116	IPVDMLCKRIADISQ	ubiquitination	[1]
170	AGYYCGFKATAAGVK	ubiquitination	[1]
177	KATAAGVKQTESTSF	ubiquitination	[1]
187	ESTSFLEKKVKKKFD	ubiquitination	[1]
188	STSFLEKKVKKKFDW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR000426; Proteasome_asu_N.
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 

Pfam

 PF00227; Proteasome
 PF10584; Proteasome_A_N 

SMART

 SM00948; Proteasome_A_N 

PROSITE

 PS00388; PROTEASOME_A_1
 PS51475; PROTEASOME_A_2 

PRINTS