CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 USP19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1260KQHREASKQLLLWRLubiquitination[1]
1288RSFIWRDKINDLVEFubiquitination[1]
1304VRNLDLSKFCIGQKEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Hydrolase; Metal-binding; Protease; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1449 AA 
Protein Sequence
PERRAGCQGP KRAGCGGLAR LSVPCWRIWP QRAAKIAGPG RKRRSPDPDA VADPGALWLS 60
TKRLKMSGGA SATGPRRGPP GLEDTTSKKK QKDRANQESK DGDPRKETGS RYVAQAGLEP 120
LASGDPSASA SHAAGITGSR HRTRLFFPSS SGSASTPQEE QTKEGACEDP HDLLATPTPE 180
LLLDWRQSAE EVIVKLRVGV GPLQLEDVDA AFTDTDCVVR FAGGQQWGGV FYAEIKSSCA 240
KVQTRKGSLL HLTLPKKVPM LTWPSLLKKP LGTQELVPGL RCQENGQELS PIALEPGPEP 300
HRAKQEARNQ KRAQGRGEVG AGAGPGAQAG PSAKRAVHLC RGPEGDGSRD DPGPRGDAPP 360
FVADPATQVE ADEQLCIPPL NSQTCLLGSE ENLAPLAGEK AVPPGNDPVS PAMVRSRNPG 420
KDHCAKEEMA VAADAATLVD EPESMVNLAF VKNDSYEKGP DSVVVHVYVK EICRDTSRVL 480
FREQDFTLIF QTRDGNFLRL HPGCGPHTTF RWQVKLRNLI EPEQCTFCFT ASRIDICLRK 540
RQSQRWGGLE APAARGAVGG AKVAVPTGPT PLDSTPPGGA PHPLTGQEEA RAVEKDKSKA 600
RSEDTGLDSV ATRTPMEHVT PKPETHLASP KPTCMVPPMP HSPVSGDSVE EEEEEEKKVC 660
LPGFTGLVNL GNTCFMNSVI QSLSNTRELR DFFHDRSFEA EINYNNPLGT GGRLAIGFAV 720
LLRALWKGTH HAFQPSKLKA IVASKASQFT GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY 780
TETVDSDGRP DEVVAEEAWQ RHKMRNDSFI VDLFQGQYKS KLVCPVCAKV SITFDPFLYL 840
PVPLPQKQKV LPVFYFAREP HSKPIKFLVS VSKENSTASE VLDSLSQSVH VKPENLRLAE 900
VIKNRFHRVF LPSHSLDTVS PSDTLLCFEL LSSELAKERV VVLEVQQRPQ VPSVPISKCA 960
ACQRKQQSED EKLKRCTRCY RVGYCNQLCQ KTHWPDHKGL CRPENIGYPF LVSVPASRLT 1020
YARLAQLLEG YARYSVSVFQ PPFQPGRMAL ESQSPGCTTL LSTGSLEAGD SERDPIQPPE 1080
LQLVTPMAEG DTGLPRVWAA PDRGPVPSTS GISSEMLASG PIEVGSLPAG ERVSRPEAAV 1140
PGYQHPSEAM NAHTPQFFIY KIDSSNREQR LEDKGDTPLE LGDDCSLALV WRNNERLQEF 1200
VLVASKELEC AEDPGSAGEA ARAGHFTLDQ CLNLFTRPEV LAPEEAWYCP QCKQHREASK 1260
QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN DLVEFPVRNL DLSKFCIGQK EEQLPSYDLY 1320
AVINHYGGMI GGHYTACARL PNDRSSQRSD VGWRLFDDST VTTVDESQVV TRYAYVLFYR 1380
RRNSPVERPP RAGHSEHHPD LGPAAEAAAS QGLGPGQAPE VAPTRTAPER FAPPVDRPAP 1440
TYSNMEEVD 1449 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR015054; DUF1872.
 IPR008978; HSP20-like_chaperone.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR002893; Znf_MYND. 
Pfam
 PF04969; CS
 PF08959; DUF1872
 PF00443; UCH
 PF01753; zf-MYND 
SMART
  
PROSITE
 PS51203; CS
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 
PRINTS