CPLM-028700

Genbank Nucleotide ID

Protein Synonyms/Alias

Catalase, isoform CRA_a

Mus musculus (Mouse)

Position	Peptide	Type	References
13	DPASDQMKQWKEQRA	acetylation	[1]
13	DPASDQMKQWKEQRA	succinylation	[1]
13	DPASDQMKQWKEQRA	ubiquitination	[2]
16	SDQMKQWKEQRASQR	acetylation	[3]
38	GGNPIGDKLNIMTAG	acetylation	[3]
38	GGNPIGDKLNIMTAG	ubiquitination	[2]
117	ENIAGHLKDAQLFIQ	acetylation	[4]
117	ENIAGHLKDAQLFIQ	ubiquitination	[2]
125	DAQLFIQKKAVKNFT	acetylation	[1, 3, 4, 5, 6, 7]
125	DAQLFIQKKAVKNFT	succinylation	[1]
125	DAQLFIQKKAVKNFT	ubiquitination	[2]
126	AQLFIQKKAVKNFTD	acetylation	[4]
129	FIQKKAVKNFTDVHP	acetylation	[1, 3, 4, 7]
129	FIQKKAVKNFTDVHP	succinylation	[1]
129	FIQKKAVKNFTDVHP	ubiquitination	[2]
148	RIQALLDKYNAEKPK	acetylation	[3, 4, 5, 6, 7]
148	RIQALLDKYNAEKPK	ubiquitination	[2]
153	LDKYNAEKPKNAIHT	acetylation	[3]
155	KYNAEKPKNAIHTYT	acetylation	[3]
171	AGSHMAAKGKANL**	acetylation	[1]
171	AGSHMAAKGKANL**	succinylation	[1]

[1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
[4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
[5] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
[6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
[7] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]

Functional Description

Complete proteome; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005778; C:peroxisomal membrane; IDA:MGI.
GO:0004046; F:aminoacylase activity; IMP:MGI.
GO:0004096; F:catalase activity; IDA:MGI.
GO:0020037; F:heme binding; IEA:InterPro.
GO:0009060; P:aerobic respiration; IMP:MGI.
GO:0008203; P:cholesterol metabolic process; IMP:MGI.
GO:0020027; P:hemoglobin metabolic process; IMP:MGI.
GO:0042744; P:hydrogen peroxide catabolic process; IDA:MGI.
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:MGI.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:MGI.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:MGI.
GO:0006641; P:triglyceride metabolic process; IMP:MGI.

IPR018028; Catalase.
IPR020835; Catalase-like_dom.
IPR024708; Catalase_AS.
IPR011614; Catalase_core.
IPR010582; Catalase_immune_responsive.

PF00199; Catalase
PF06628; Catalase-rel

PS00438; CATALASE_2
PS51402; CATALASE_3