CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038648
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinesin-1 heavy chain 
Protein Synonyms/Alias
  
Gene Name
 Kif5b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10DPAECNIKVMCRFRPacetylation[1]
159NLSVHEDKNRVPYVKacetylation[1]
166KNRVPYVKGCTERFVubiquitination[2]
226TEQKLSGKLYLVDLAubiquitination[2]
237VDLAGSEKVSKTGAEubiquitination[2]
240AGSEKVSKTGAEGAVacetylation[1]
240AGSEKVSKTGAEGAVubiquitination[2]
252GAVLDEAKNINKSLSubiquitination[2]
382PIDEQFDKEKANLEAacetylation[3]
420FTDAERRKCEEELAKubiquitination[2]
539SIDAELQKLKEMTNHubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 619 AA 
Protein Sequence
MADPAECNIK VMCRFRPLNE SEVNRGDKYV AKFQGEDTVM IASKPYAFDR VFQSSTSQEQ 60
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 120
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 180
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 240
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 300
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKTLRNTIQW 360
LENELNRWRN GETVPIDEQF DKEKANLEAF TADKDIAITS DKPAAAVGMA GSFTDAERRK 420
CEEELAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE 480
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL 540
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE 600
VKTMVKRCKQ LESTQTESN 619 
Gene Ontology
 GO:0035253; C:ciliary rootlet; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005871; C:kinesin complex; TAS:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; TAS:MGI.
 GO:0007028; P:cytoplasm organization; IMP:MGI.
 GO:0007017; P:microtubule-based process; TAS:MGI.
 GO:0006839; P:mitochondrial transport; TAS:MGI.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.