CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010754
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphate carrier protein, mitochondrial 
Protein Synonyms/Alias
 Phosphate transport protein; PTP; Solute carrier family 25 member 3 
Gene Name
 SLC25A3 
Gene Synonyms/Alias
 PHC; OK/SW-cl.48 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98RMQVDPQKYKGIFNGubiquitination[1]
205TLRDAAPKMYKEEGLubiquitination[1]
208DAAPKMYKEEGLKAFubiquitination[1]
217EGLKAFYKGVAPLWMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). 
Sequence Annotation
 REPEAT 63 147 Solcar 1.
 REPEAT 160 244 Solcar 2.
 REPEAT 261 339 Solcar 3.
 MOD_RES 99 99 N6-acetyllysine.
 MOD_RES 196 196 Phosphotyrosine.
 MOD_RES 209 209 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Disease mutation; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Symport; Transit peptide; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEYSCEFGS 60
AKYYALCGFG GVLSCGLTHT AVVPLDLVKC RMQVDPQKYK GIFNGFSVTL KEDGVRGLAK 120
GWAPTFLGYS MQGLCKFGFY EVFKVLYSNM LGEENTYLWR TSLYLAASAS AEFFADIALA 180
PMEAAKVRIQ TQPGYANTLR DAAPKMYKEE GLKAFYKGVA PLWMRQIPYT MMKFACFERT 240
VEALYKFVVP KPRSECSKPE QLVVTFVAGY IAGVFCAIVS HPADSVVSVL NKEKGSSASL 300
VLKRLGFKGV WKGLFARIIM IGTLTALQWF IYDSVKVYFR LPRPPPPEMP ESLKKKLGLT 360
Q 361 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005743; C:mitochondrial inner membrane; TAS:ProtInc.
 GO:0015320; F:phosphate ion carrier activity; TAS:ProtInc.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS