CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036174
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MCCC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
154VLFSESAKKGTHFVQubiquitination[1]
192YEAEGIAKDGAKMVAubiquitination[1, 2, 3]
259NVLATITKDQRAREGubiquitination[1, 3]
278SADEAALKEPIIKKFubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MADENIIVRK QGTIFLAGPP LVKAATGEEV SAEDLGGADL HCRKSGVSDH WALDDHHALH 60
LTRKVVRNLN YQKKLDVTIE PSEEPLFPAD ELYGIVGANL KRSFDVREKF FMKYFLRLDL 120
NSYNSTWQHG FARIFGYPVG IVGNNGVLFS ESAKKGTHFV QLCCQRNIPL LFLQNITGFM 180
VGREYEAEGI AKDGAKMVAA VACAQVPKIT LIIGGSYGAG NYGMCGRAYS PRFLYIWPNA 240
RISVMGGEQA ANVLATITKD QRAREGKQFS SADEAALKEP IIKKFE 286 
Gene Ontology
 GO:0016874; F:ligase activity; IEA:InterPro. 
Interpro
 IPR000022; Carboxyl_trans.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N. 
Pfam
 PF01039; Carboxyl_trans 
SMART
  
PROSITE
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER 
PRINTS