UniProt Accession

 SMRCD_RAT; D3Z9Z9 

Genbank Protein ID

 AABR03032021 

Genbank Nucleotide ID

  

Protein Name

 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 

Protein Synonyms/Alias

  

Gene Name

 Smarcad1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
333	MKQKISMKPQNGFNK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity). 

Sequence Annotation

 DOMAIN 156 198 CUE 1.
 DOMAIN 250 293 CUE 2.
 DOMAIN 507 675 Helicase ATP-binding.
 DOMAIN 856 1008 Helicase C-terminal.
 NP_BIND 519 527 ATP (By similarity).
 NP_BIND 895 902 ATP (By similarity).
 MOTIF 626 629 DEGH box (By similarity).
 MOTIF 719 736 Nuclear localization signal (Potential).
 MOTIF 1003 1006 DEAD box (By similarity).
 MOD_RES 54 54 Phosphothreonine (By similarity).
 MOD_RES 57 57 Phosphoserine (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 127 127 Phosphoserine (By similarity).
 MOD_RES 132 132 Phosphoserine (By similarity).
 MOD_RES 137 137 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphoserine (By similarity).
 MOD_RES 151 151 Phosphoserine (By similarity).
 MOD_RES 210 210 Phosphoserine (By similarity).
 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 238 238 Phosphoserine (By similarity).
 MOD_RES 241 241 Phosphoserine (By similarity).
 MOD_RES 301 301 Phosphoserine (By similarity).
 MOD_RES 406 406 Phosphoserine (By similarity).  

Keyword

 ATP-binding; Chromatin regulator; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1024 AA 

Protein Sequence

Gene Ontology

 GO:0000792; C:heterochromatin; ISS:UniProtKB.
 GO:0043596; C:nuclear replication fork; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0035861; C:site of double-strand break; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
 GO:0043044; P:ATP-dependent chromatin remodeling; ISS:UniProtKB.
 GO:0051304; P:chromosome separation; ISS:UniProtKB.
 GO:0000729; P:DNA double-strand break processing; ISS:UniProtKB.
 GO:0070932; P:histone H3 deacetylation; ISS:UniProtKB.
 GO:0070933; P:histone H4 deacetylation; ISS:UniProtKB.
 GO:0000018; P:regulation of DNA recombination; IEA:Compara. 

Interpro

 IPR003892; CUE.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 

Pfam

 PF00271; Helicase_C
 PF00176; SNF2_N 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS51140; CUE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 

PRINTS