UniProt Accession

 ARV1_HUMAN; Q9H2C2; A8KAI4; Q5VSN7; Q5VSN8; Q5VSN9; Q5VSP0; Q5VSP2; Q9H2H2; Q9H5V6; Q9UFF5 

Genbank Protein ID

 AF290878; AF321442; AF271780; AK026629; AK293049; AL732414; AL844165; AL732414; AL844165; AL732414; AL844165; AL732414; AL844165; AL844165; AL732414; AL844165; AL732414; AL844165; AL732414; AL844165; AL732414; CH471098; BC016309; AL122047 

Genbank Nucleotide ID

 AAG47671.1; AAK11180.1; AAG44791.1; BAB15513.1; BAF85738.1; CAH73698.1; CAH73698.1; CAH73699.1; CAH73699.1; CAH73700.1; CAH73700.1; CAH73701.1; CAH73701.1; CAI15332.1; CAI15332.1; CAI15333.1; CAI15333.1; CAI15334.1; CAI15334.1; CAI15335.1; CAI15335.1; EAW69935.1; AAH16309.1; CAB59183.3 

Protein Name

 Protein ARV1 

Protein Synonyms/Alias

 hARV1 

Gene Name

 ARV1 

Gene Synonyms/Alias

 HT035 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	RSGLQQGKGNVDGVA	ubiquitination	[1]
42	IECNQEAKELYRDYN	ubiquitination	[1]
136	DDLIRYAKEWDFYRM	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May act as a mediator of sterol homeostasis (Potential). 

Sequence Annotation

  

Keyword

 Complete proteome; Lipid metabolism; Membrane; Polymorphism; Reference proteome; Sphingolipid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008206; P:bile acid metabolic process; IEA:Compara.
 GO:0030301; P:cholesterol transport; IEA:Compara.
 GO:0090181; P:regulation of cholesterol metabolic process; IEA:Compara.
 GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR007290; Arv1. 

Pfam

 PF04161; Arv1 

SMART

  

PROSITE

  

PRINTS