CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020967
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase RIO3 
Protein Synonyms/Alias
 RIO kinase 3 
Gene Name
 Riok3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
108KKFNGDSKVSISFENubiquitination[1]
300KTTLNEFKNRDKYIKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 251 519 Protein kinase.
 NP_BIND 257 265 ATP (By similarity).
 ACT_SITE 406 406 Proton acceptor (By similarity).
 BINDING 290 290 ATP (By similarity).
 MOD_RES 127 127 Phosphoserine (By similarity).
 MOD_RES 128 128 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 519 AA 
Protein Sequence
MDLVGVSSPE PGPAAAWGPS KCPWATPQNT VSCSLTEVMS EELAKELQLE EEAAAFPEVV 60
VAEGPFISGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH 120
PFEDSDSSED EVDWQDTRDD PYRPAKPIPT PKKGFIGKGK DITTKHDEVV CGRKNTARME 180
NFAPGFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL 240
MYKMVNSGML ETITGCISTG KESVVFHAYG GSLEDEKEDG KAIPTECAIK VFKTTLNEFK 300
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ KAGIPCPTVV LLKKHILVMS 360
FIGHDQVPAP KLKEVKLSNE EMKDAYYQTL HLMQQLYNEC TLVHADLSEY NMLWHAGKVW 420
LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVTEALN ERELFNAVSG LNISADNEAD 480
FLAEIEALEK MNEDHIQKNG RKAASFLKDD GSPPVLSAD 519 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR018934; RIO-like_kinase.
 IPR000687; RIO_kinase.
 IPR018935; RIO_kinase_CS.
 IPR017406; Ser/Thr_kinase_Rio3. 
Pfam
 PF01163; RIO1 
SMART
 SM00090; RIO 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS01245; RIO1 
PRINTS