CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016693
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein fem-1 homolog A-B 
Protein Synonyms/Alias
 FEM1a-B; FEM1-alpha-B 
Gene Name
 Fem1ab 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
15YNAAHDGKLPLLQKLubiquitination[1]
296LGATYVDKKRDLLGAubiquitination[1]
609AYELLDSKLLAKSTVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity). 
Sequence Annotation
 REPEAT 2 31 ANK 1.
 REPEAT 40 70 ANK 2.
 REPEAT 82 111 ANK 3.
 REPEAT 115 145 ANK 4.
 REPEAT 149 178 ANK 5.
 REPEAT 182 211 ANK 6.
 REPEAT 214 243 ANK 7.
 REPEAT 283 317 TPR 1.
 REPEAT 375 408 TPR 2.
 REPEAT 519 561 ANK 8.
 REPEAT 565 594 ANK 9.  
Keyword
 ANK repeat; Complete proteome; Cytoplasm; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 654 AA 
Protein Sequence
MDLHTAVYNA AHDGKLPLLQ KLLASRGREE LEELLGEVAG GGTPLLIAAR RGHLDVVEYL 60
VDHCGASVEA SGSVHFDGET IEGAPPLWAA SAAGHLAVVR SLLHRGASVN RTTCTNSTPL 120
RAACFNGHLD VVRCLVGEHK ADLEVANRHG HTCLMISCYK GHREIARYLL ERGAQVNRRS 180
AKGNTALHDC AESGSLEILQ LLLSCHARME RDGYGMTPLL AASITGHTNI VEYLIQEQPS 240
HEQLSGTELP GEGSSQMAGN HCSTPEDAEQ YESCCPTSRE AAVEALELLG ATYVDKKRDL 300
LGALKHWRRA MELRHQGGGF LPKPEPQQLV LAYDYSREVT TPQELEALIT DPDEMRMQAL 360
LIRERILGPS HPDTSYYIRY RGAVYADSGN FERCIRLWKY ALDMQQNNLE PLSPMTASSF 420
LSFAELFSYV LQDHSAKGNL GMQLDFADLI GVLSKGVREV ERALQLPKEP DDSAQFTKAI 480
AIILHLLYLL EKVECTPRQE HLKHQTVYRL LKCAPRGKNG FTPLHMAVDK ETTNVGQYHV 540
GVFPSLQVVK VLLDCGADPD SRDFDNNSPL HIAAQNNCPA IMDALIEAGA HMDATNTFKK 600
TAYELLDSKL LAKSTVQPFN YVTLQCLAAR ALDRNKVPYK GFIPEELEAF IQLH 654 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0051438; P:regulation of ubiquitin-protein ligase activity; ISS:UniProtKB. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011990; TPR-like_helical. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS
 PR01415; ANKYRIN.