UniProt Accession

 RL22_ECOLI; P61175; P02423; Q2M6Y0 

Genbank Protein ID

 X02613; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA26465.1; AAA58112.1; AAC76340.1; BAE77976.1 

Protein Name

 50S ribosomal protein L22 

Protein Synonyms/Alias

  

Gene Name

 rplV 

Gene Synonyms/Alias

 eryB; b3315; JW3277 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
28	ADLIRGKKVSQALDI	acetylation	[1]
41	DILTYTNKKAAVLVK	acetylation	[2]
48	KKAAVLVKKVLESAI	acetylation	[2]
70	GADIDDLKVTKIFVD	acetylation	[2]
73	IDDLKVTKIFVDEGP	acetylation	[2]
83	VDEGPSMKRIMPRAK	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. 

Sequence Annotation

  

Keyword

 3D-structure; Antibiotic resistance; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0019843; F:rRNA binding; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR001063; Ribosomal_L22.
 IPR018260; Ribosomal_L22/L17_CS.
 IPR005727; Ribosomal_L22_bac/chlpt-type. 

Pfam

 PF00237; Ribosomal_L22 

SMART

  

PROSITE

 PS00464; RIBOSOMAL_L22 

PRINTS