UniProt Accession

 PRDX4_HUMAN; Q13162; Q6FHT3 

Genbank Protein ID

 U25182; CR541668; CR541705; BC003609; BC007107; BC016770 

Genbank Nucleotide ID

 AAB95175.1; CAG46469.1; CAG46506.1; AAH03609.1; AAH07107.1; AAH16770.1 

Protein Name

 Peroxiredoxin-4 

Protein Synonyms/Alias

 Antioxidant enzyme AOE372; AOE37-2; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372 

Gene Name

 PRDX4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
208	GLFIIDDKGILRQIT	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. 

Sequence Annotation

 DOMAIN 79 237 Thioredoxin.
 ACT_SITE 124 124 Cysteine sulfenic acid (-SOH)
 DISULFID 124 124 Interchain (with C-245); in linked form
 DISULFID 245 245 Interchain (with C-124); in linked form  

Keyword

 3D-structure; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008379; F:thioredoxin peroxidase activity; TAS:ProtInc.
 GO:0007252; P:I-kappaB phosphorylation; TAS:ProtInc.
 GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS