UniProt Accession

 TSN_MOUSE; Q62348 

Genbank Protein ID

 X81464; Y12568; Y12569; Y12570; Y12571; Y12572; BC004615 

Genbank Nucleotide ID

 CAA57222.1; CAA73151.1; CAA73151.1; CAA73151.1; CAA73151.1; CAA73151.1; AAH04615.1 

Protein Name

 Translin 

Protein Synonyms/Alias

 Component 3 of promoter of RISC; C3PO; Testis/brain RNA-binding protein; TB-RBP 

Gene Name

 Tsn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	TGFQDIPKRCLKARE	ubiquitination	[1]
187	GFRLLNLKNDSLRKR	ubiquitination	[1]
219	LSIRGFNKETAAACG	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. 

Sequence Annotation

 REGION 86 90 DNA/RNA binding.
 REGION 177 198 Leucine-zipper (Potential).
 MOD_RES 187 187 N6-acetyllysine (By similarity).
 MOD_RES 199 199 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 

Interpro

 IPR002848; Translin.
 IPR016069; Translin_C.
 IPR016068; Translin_N. 

Pfam

 PF01997; Translin 

SMART

  

PROSITE

  

PRINTS