CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027663
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thymidylate synthase 
Protein Synonyms/Alias
  
Gene Name
 TS 
Gene Synonyms/Alias
 TYMS; hCG_1994842 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86QRVIDTIKTNPDDRRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 230 AA 
Protein Sequence
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG 60
MQARYSLRDY SGQGVDQLQR VIDTIKTNPD DRRIIMCAWN PRDLPLMALP PCHALCQFYV 120
VNSELSCQLY QRSGDMGLGV PFNIASYALL TYMIAHITGL KPGDFIHTLG DAHIYLNHIE 180
PLKIQLQREP RPFPKLRILR KVEKIDDFKA EDFQIEGYNP HPTIKMEMAV 230 
Gene Ontology
 GO:0004799; F:thymidylate synthase activity; IEA:EC.
 GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
 GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR023451; Thymidate_synth/dCMP_Mease.
 IPR000398; Thymidylate_synthase.
 IPR020940; Thymidylate_synthase_AS. 
Pfam
 PF00303; Thymidylat_synt 
SMART
  
PROSITE
 PS00091; THYMIDYLATE_SYNTHASE 
PRINTS
 PR00108; THYMDSNTHASE.