CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002865
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine decarboxylase, inducible 
Protein Synonyms/Alias
 LDC 
Gene Name
 cadA 
Gene Synonyms/Alias
 ldcI; STM2559 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
707ADGRYTVKVLKENTKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 MOD_RES 367 367 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Cytoplasm; Decarboxylase; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 714 AA 
Protein Sequence
MNVIAIMNHM GVYFKEEPIR ELHRALEGLN FRIVYPNDRE DLLKLIENNS RLCGVIFDWD 60
KYNLELCEEI SKLNEYMPLY AFANSYSTLD VSLNDLRMQV RFFEYALGAA ADIAAKIRQN 120
TDEYIDNILP PLTKALFKYV REGKYTFCTP GHMGGTAFQK SPVGSIFYDF FGPNTMKSDI 180
SISVSELGSL LDHSGPHKEA EEYIARVFNA ERSYMVTNGT STANKIVGMY SAPAGSTVLI 240
DRNCHKSLTH LMMMSDITPI YFRPTRNAYG ILGGIPQSEF QHATIAKRVK ETPNATWPVH 300
AVITNSTYDG LLYNTDYIKK TLDVKSIHFD SAWVPYTNFS PIYQGKCGMS GDRVEGKIIY 360
ETQSTHKLLA AFSQASMIHV KGDINEETFN EAYMMHTTTS PHYGIVASTE TAAAMMKGNA 420
GKRLINGSIE RAIKFRKEIK RLKSESDGWF FDVWQPEHID GAECWPLRSD SAWHGFKNID 480
NEHMYLDPIK VTILTPGMKK DGTMDEFGIP ASLVAKYLDE RGIIVEKTGP YNLLFLFSIG 540
IDKTKALSLL RALTEFKRAF DLNLRVKNIL PALYREAPEF YENMRIQELA QNIHKLVEHH 600
NLPDLMYRAF EVLPKMVMTP YTAFQKELHG ETEEVYLEEM VGRVNANMIL PYPPGVPLVM 660
PGEMITEESR PVLEFLQMLC EIGAHYPGFE TDIHGAYRQA DGRYTVKVLK ENTK 714 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008923; F:lysine decarboxylase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 
Interpro
 IPR005308; OKR_de-COase_N.
 IPR011193; Orn/lys/arg_de-COase.
 IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
 IPR008286; Prn/Lys/Arg_de-COase_C.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF01276; OKR_DC_1
 PF03711; OKR_DC_1_C
 PF03709; OKR_DC_1_N 
SMART
  
PROSITE
 PS00703; OKR_DC_1 
PRINTS