| Tag | Content |
|---|
| CPLM ID | CPLM-010783 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
Protein Synonyms/Alias | Flavoprotein subunit of complex II; FP |
Gene Name | SDH1 |
Gene Synonyms/Alias | SDHA; YKL148C; YKL602 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 537 | RNITAVEKTFDDVKT | acetylation | [1] | | 616 | VAAPVTLKYRRVIDH | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4. |
Sequence Annotation | NP_BIND 59 64 FAD (By similarity).
NP_BIND 82 97 FAD (By similarity).
NP_BIND 449 450 FAD (By similarity).
ACT_SITE 331 331 Proton acceptor (By similarity).
BINDING 266 266 FAD (By similarity).
BINDING 287 287 Substrate (By similarity).
BINDING 299 299 Substrate (By similarity).
BINDING 398 398 Substrate (By similarity).
BINDING 433 433 FAD (By similarity).
BINDING 444 444 Substrate (By similarity).
MOD_RES 90 90 Tele-8alpha-FAD histidine (By |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 640 AA |
Protein Sequence | MLSLKKSALS KLTLLRNTRT FTSSALVRQT QGSVNGSASR SADGKYHIID HEYDCVVIGA 60
GGAGLRAAFG LAEAGYKTAC ISKLFPTRSH TVAAQGGINA ALGNMHKDNW KWHMYDTVKG 120
SDWLGDQDSI HYMTREAPKS IIELEHYGVP FSRTENGKIY QRAFGGQTKE YGKGAQAYRT 180
CAVADRTGHA LLHTLYGQAL RHDTHFFIEY FALDLLTHNG EVVGVIAYNQ EDGTIHRFRA 240
HKTIIATGGY GRAYFSCTSA HTCTGDGNAM VSRAGFPLQD LEFVQFHPSG IYGSGCLITE 300
GARGEGGFLV NSEGERFMER YAPTAKDLAC RDVVSRAITM EIREGRGVGK KKDHMYLQLS 360
HLPPEVLKER LPGISETAAI FAGVDVTKEP IPIIPTVHYN MGGIPTKWNG EALTIDEETG 420
EDKVIPGLMA CGEAACVSVH GANRLGANSL LDLVVFGRAV AHTVADTLQP GLPHKPLPSD 480
LGKESIANLD KLRNANGSRS TAEIRMNMKQ TMQKDVSVFR TQSSLDEGVR NITAVEKTFD 540
DVKTTDRSMI WNSDLVETLE LQNLLTCASQ TAVSAANRKE SRGAHAREDY PNRDDEHWMK 600
HTLSWQKDVA APVTLKYRRV IDHTLDEKEC PSVPPTVRAY 640 |
Gene Ontology | GO:0005749; C:mitochondrial respiratory chain complex II; IDA:SGD. GO:0050660; F:flavin adenine dinucleotide binding; IDA:SGD. GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IDA:SGD. GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IDA:SGD. GO:0006099; P:tricarboxylic acid cycle; IC:SGD. |
Interpro | |
Pfam | |
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PROSITE | |
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