CPLM-013116

Genbank Nucleotide ID

F-box/WD repeat-containing protein 1A

Protein Synonyms/Alias

Beta-TrCP protein E3RS-IkappaB; Beta-transducin repeat-containing protein; Beta-TrCP; E3RSIkappaB; mE3RS-IkappaB; F-box and WD repeats protein beta-TrCP; HOS; Ubiquitin ligase FWD1; pIkappaB-E3 receptor subunit

Fbw1; Fbxw1; Fwd1; Kiaa4123

Mus musculus (Mouse)

Position	Peptide	Type	References
437	NVVDFDDKYIVSASG	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

DOMAIN 182 228 F-box.
REPEAT 301 338 WD 1.
REPEAT 341 378 WD 2.
REPEAT 381 418 WD 3.
REPEAT 424 461 WD 4.
REPEAT 464 503 WD 5.
REPEAT 505 541 WD 6.
REPEAT 553 590 WD 7.
REGION 128 177 Homodimerization domain D (By
REGION 190 228 Required for down-regulation of SNAI1 (By

Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat; Wnt signaling pathway.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.
GO:0045309; F:protein phosphorylated amino acid binding; IDA:BHF-UCL.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL.
GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
GO:0033598; P:mammary gland epithelial cell proliferation; IMP:MGI.
GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
GO:0042753; P:positive regulation of circadian rhythm; IMP:UniProtKB.
GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.
GO:0031648; P:protein destabilization; ISS:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:BHF-UCL.
GO:0051726; P:regulation of cell cycle; IMP:MGI.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI.
GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:MGI.
GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.

IPR021977; Beta-TrCP_D.
IPR001810; F-box_dom_cyclin-like.
IPR020472; G-protein_beta_WD-40_rep.
IPR015943; WD40/YVTN_repeat-like_dom.
IPR001680; WD40_repeat.
IPR019775; WD40_repeat_CS.
IPR017986; WD40_repeat_dom.

PF12125; Beta-TrCP_D
PF00400; WD40

SM01028; Beta-TrCP_D
SM00256; FBOX
SM00320; WD40

PS50181; FBOX
PS00678; WD_REPEATS_1
PS50082; WD_REPEATS_2
PS50294; WD_REPEATS_REGION

PR00320; GPROTEINBRPT.