UniProt Accession

 LTOR2_HUMAN; Q9Y2Q5; Q5VY97; Q5VY98; Q5VY99 

Genbank Protein ID

 AF070659; AK307086; AL355388; AL355388; AL355388; BC024190 

Genbank Nucleotide ID

 AAD20965.1; CAH72635.1; CAH72636.1; CAH72637.1; AAH24190.1 

Protein Name

 Ragulator complex protein LAMTOR2 

Protein Synonyms/Alias

 Endosomal adaptor protein p14; Late endosomal/lysosomal Mp1-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; Mitogen-activated protein-binding protein-interacting protein; Roadblock domain-containing protein 3 

Gene Name

 LAMTOR2 

Gene Synonyms/Alias

 MAPBPIP; ROBLD3; HSPC003 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	AFNEDNLKFILMDCM	ubiquitination	[1]
107	GFGMLKAKAQALVQY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. 

Sequence Annotation

 REGION 57 70 Required for location at endosomes (By  

Keyword

 Alternative splicing; Complete proteome; Endosome; Lysosome; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 125 AA 

Protein Sequence

Gene Ontology

 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0071986; C:Ragulator complex; IDA:UniProtKB.
 GO:0000186; P:activation of MAPKK activity; IEA:Compara.
 GO:0016049; P:cell growth; IMP:UniProtKB.
 GO:0034613; P:cellular protein localization; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB. 

Interpro

 IPR004942; Dynein_light-rel. 

Pfam

 PF03259; Robl_LC7 

SMART

 SM00960; Robl_LC7 

PROSITE

  

PRINTS