CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038061
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glucocorticoid receptor 
Protein Synonyms/Alias
  
Gene Name
 Nr3c1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
297LPQVKTEKDDFIELCubiquitination[1]
514RKTKKKIKGIQQATAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 792 AA 
Protein Sequence
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 60
RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV SLSMGLYMGE TETKVMGNDL 120
GYPQQGQLGL SSGETDFRLL EESIANLNRS TSRPENPKSS TPAAGCATPT EKEFPQTHSD 180
PSSEQQNRKS QPGTNGGSVK LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN 240
LLSPLAGEDD PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH YDMNTASLSQ 360
QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF AGRSVFSNGY SSPGMRPDVS 420
SPPSSSSTAT GPPPKLCLVC SDEASGCHYG VLTCGSCKVF FKRAVEGQHN YLCAGRNDCI 480
IDKIRRKNCP ACRYRKCLQA GMNLEARKTK KKIKGIQQAT AGVSQDTSEN ANKTIVPAAL 540
PQLTPTLVSL LEVIEPEVLY AGYDSSVPDS AWRIMTTLNM LGGRQVIAAV KWAKAIPGFR 600
NLHLDDQMTL LQYSWMFLMA FALGWRSYRQ ASGNLLCFAP DLIINEQRMT LPCMYDQCKH 660
MLFISTELQR LQVSYEEYLC MKTLLLLSSV PKEGLKSQEL FDEIRMTYIK ELGKAIVKRE 720
GNSSQNWQRF YQLTKLLDSM HDVVENLLSY CFQTFLDKSM SIEFPEMLAE IITNQIPKYS 780
NGNIKKLLFH QK 792 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004883; F:glucocorticoid receptor activity; IDA:MGI.
 GO:0046983; F:protein dimerization activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IMP:MGI.
 GO:0008211; P:glucocorticoid metabolic process; IMP:MGI.
 GO:0060603; P:mammary gland duct morphogenesis; IMP:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IGI:MGI.
 GO:0031946; P:regulation of glucocorticoid biosynthetic process; IMP:MGI.
 GO:0006111; P:regulation of gluconeogenesis; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001409; Glcrtcd_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF02155; GCR
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00528; GLCORTICOIDR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.