CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000820
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit delta-1 
Protein Synonyms/Alias
 AP-3 complex subunit delta; Adapter-related protein complex 3 subunit delta-1; Delta-adaptin; mBLVR1 
Gene Name
 Ap3d1 
Gene Synonyms/Alias
 Ap3d 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
34NHKEDEAKYISQCIDubiquitination[1]
352ILQCLDDKDESIRLRubiquitination[1]
610ELNPVAPKAQKKVPVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
Sequence Annotation
 REPEAT 34 71 HEAT 1.
 REPEAT 142 179 HEAT 2.
 REPEAT 180 216 HEAT 3.
 REPEAT 218 254 HEAT 4.
 REPEAT 257 296 HEAT 5.
 REPEAT 298 336 HEAT 6.
 REPEAT 337 373 HEAT 7.
 REPEAT 375 409 HEAT 8.
 REPEAT 521 558 HEAT 9.
 MOD_RES 632 632 Phosphoserine.
 MOD_RES 634 634 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 688 688 Phosphoserine (By similarity).
 MOD_RES 754 754 Phosphoserine.
 MOD_RES 755 755 Phosphoserine.
 MOD_RES 758 758 Phosphothreonine.
 MOD_RES 760 760 Phosphoserine.
 MOD_RES 784 784 Phosphoserine.
 MOD_RES 825 825 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1199 AA 
Protein Sequence
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 60
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRVGYLAASQ CFHEGTDVIM LTTNQIRKDL 120
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 180
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 240
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 300
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 360
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ HITNFEWYIS 420
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS SLLDSAHLVA SSTQRNGICE 480
VLYAAAWICG EFSEHLQGPQ QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 540
ADTEAAQEVT QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKGV PVAEEVSALF 600
AGELNPVAPK AQKKVPVPEG LDLDAWINEP PSDSESEDEK PKAIFHEEEP RHTRRRQPEE 660
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDAPGVE HIPVVQIDLS VPLKVPGMPM 720
SDQYVKLEEQ RRHRQRLEKD KKRKKKEKGK RRHSSLPTES DEDIAPAQRV DIITEEMPEN 780
ALPSDEDDKD PNDPYRALDI DLDKPLADSE KLPVQKHRNA EAVKSPEKEG VLGVEKKSKK 840
PKKKEKKTKE REREKKDKKG EDLDFWLSTT PPPAAAPIPA PSTEELAAST ITSPKDECEV 900
LKGEEEDHVD HDQERKSSRH KKKKHRKEKE KEERPRDKKK AKKKQVAPLE NGAAAEEEEE 960
PIPPMSSYCL LAESPYIKVT YDIQASLQKD SQVTVSIILE NQSSSFLKNM ELNVLDSLNT 1020
KMTRPEGSSV HDGVPVPFQL PPGVSNEAQF VFTIQSIVMA QKLKGTLSFI AKDDEGATHE 1080
KLDFRLHFSC SSYLITTPCY SDAFAKLLES GDLSMNSIKV DGISMSFQNL LAKICFYHHF 1140
SVVERVDSCA SMYSRSIQGH HVCLLVKKGE SSVSVDGKCS DATLLSSLLE EMKTTLAQC 1199 
Gene Ontology
 GO:0010008; C:endosome membrane; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0030117; C:membrane coat; IEA:InterPro.
 GO:0043195; C:terminal bouton; IDA:MGI.
 GO:0005802; C:trans-Golgi network; TAS:MGI.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IMP:MGI.
 GO:0006886; P:intracellular protein transport; IMP:MGI.
 GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI.
 GO:0033365; P:protein localization to organelle; IMP:MGI.
 GO:0061088; P:regulation of sequestering of zinc ion; TAS:BHF-UCL.
 GO:0048499; P:synaptic vesicle membrane organization; IMP:MGI.
 GO:0006829; P:zinc ion transport; TAS:BHF-UCL. 
Interpro
 IPR017105; AP3_complex_dsu.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR010474; BLV_receptor.
 IPR002553; Clathrin/coatomer_adapt-like_N. 
Pfam
 PF01602; Adaptin_N
 PF06375; BLVR 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS