CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017130
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA (uracil-5-)-methyltransferase homolog A 
Protein Synonyms/Alias
 HpaII tiny fragments locus 9c protein 
Gene Name
 TRMT2A 
Gene Synonyms/Alias
 HTF9C 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
290EATKQVVKAFQEFIRubiquitination[1]
314ETYTGHWKQLTVRTSubiquitination[1]
346PEELAELKTSLAQHFubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in nucleic acid metabolism and/or modifications. 
Sequence Annotation
 DOMAIN 73 146 RRM.
 MOD_RES 602 602 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 625 AA 
Protein Sequence
MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY 60
SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA 120
ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE SEPPVTRVAD VVTPLWTVPY 180
AEQLERKQLE CEQVLQKLAK EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR 240
NKCEFLVGVG VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP 300
YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA QHFTAGPGRA 360
SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL TFRISPHAFF QVNTPAAEVL 420
YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL ARKVKRVIGV ELCPEAVEDA RVNAQDNELS 480
NVEFHCGRAE DLVPTLVSRL ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP 540
RAAMGNFVDL CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP 600
HSPPAQPTPG PPDNTLQETG TFPSS 625 
Gene Ontology
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
 GO:0001510; P:RNA methylation; IEA:GOC.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR010280; U5_MeTrfase. 
Pfam
 PF05958; tRNA_U5-meth_tr 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS