| Tag | Content |
|---|
| CPLM ID | CPLM-014798 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta |
Protein Synonyms/Alias | GlcNAc-1-phosphotransferase subunits alpha/beta; Stealth protein GNPTAB; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta |
Gene Name | Gnptab |
Gene Synonyms/Alias | Gnpta; Kiaa1208 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1082 | PVTDKIHKAYKDKNK | acetylation | [1] |
|
Reference | [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. J Biol Chem. 2013 Jul 17;. [ PMID: 23864654] |
Functional Description | Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment (By similarity). |
Sequence Annotation | REPEAT 438 473 LNR 1.
REPEAT 505 545 LNR 2.
DOMAIN 984 1019 EF-hand.
METAL 449 449 Calcium (By similarity).
METAL 464 464 Calcium (By similarity).
METAL 467 467 Calcium (By similarity).
METAL 516 516 Calcium (By similarity).
METAL 531 531 Calcium (By similarity).
METAL 534 534 Calcium (By similarity).
CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
CARBOHYD 148 148 N-linked (GlcNAc...) (Potential).
CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
CARBOHYD 614 614 N-linked (GlcNAc...) (Potential).
CARBOHYD 729 729 N-linked (GlcNAc...) (Potential).
CARBOHYD 988 988 N-linked (GlcNAc...) (Potential).
CARBOHYD 1108 1108 N-linked (GlcNAc...) (Potential).
DISULFID 438 461 By similarity.
DISULFID 452 468 By similarity.
DISULFID 505 528 By similarity.
DISULFID 519 535 By similarity. |
Keyword | Alternative splicing; Calcium; Complete proteome; Disulfide bond; Glycoprotein; Golgi apparatus; Membrane; Metal-binding; Reference proteome; Repeat; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1235 AA |
Protein Sequence | MLLKLLQRQT YTCLSHRYGL YVCFVGVVVT IVSAFQFGEV VLEWSRDQYH VLFDSYRDNI 60
AGKSFQNRLC LPMPIDVVYT WVNGTDLELL KELQQVREHM EEEQRAMRET LGKNTTEPTK 120
KSEKQLECLL THCIKVPMLV LDPPLPANCT LKDLPTLYPS FHAASDMFNV AKPKNPSTNV 180
SVVVFDTTKD VEDAHAGPFK GGSKQMVWRA YLTTDKEAPG LVLMQGLAFL SGFPPTFKET 240
SQLKTKLPEK LSSKIKLLRL YSEASVALLK LNNPKGFQEL NKQTKKNMTI DGKELTISPA 300
YLLWDLSAIS QSKQDEDVSA SRFEDNEELR YSLRSIERHA PWVRNIFIVT NGQIPSWLNL 360
DNPRVTIVTH QDIFQNLSHL PTFSSPAIES HIHRIEGLSQ KFIYLNDDVM FGKDVWPDDF 420
YSHSKGQKVY LTWPVPNCAE GCPGSWIKDG YCDKACNNSA CDWDGGDCSG NTAGNRFVAG 480
GGGTGNIGAG QHWQFGGGIN TISYCNQGCA NSWLADKFCD QACNVLSCGF DAGDCGQDHF 540
HELYKVTLLP NQTHYVVPKG EYLSYFSFAN IARRGVEGTY SDNPIIRHAS IANKWKTIHL 600
IMHSGMNATT IYFNLTLQNA NDEEFKIQIA VEVDTREAPK LNSTTQKAYE SLVSPVTPLP 660
QADVPFEDVP KEKRFPKIRR HDVNATGRFQ EEVKIPRVNI SLLPKEAQVR LSNLDLQLER 720
GDITLKGYNL SKSALLRSFL GNSLDTKIKP QARTDETKGN LEVPQENPSH RRPHGFAGEH 780
RSERWTAPAE TVTVKGRDHA LNPPPVLETN ARLAQPTLGV TVSKENLSPL IVPPESHLPK 840
EEESDRAEGN AVPVKELVPG RRLQQNYPGF LPWEKKKYFQ DLLDEEESLK TQLAYFTDSK 900
HTGRQLKDTF ADSLRYVNKI LNSKFGFTSR KVPAHMPHMI DRIVMQELQD MFPEEFDKTS 960
FHKVRHSEDM QFAFSYFYYL MSAVQPLNIS QVFHEVDTDQ SGVLSDREIR TLATRIHDLP 1020
LSLQDLTGLE HMLINCSKML PANITQLNNI PPTQEAYYDP NLPPVTKSLV TNCKPVTDKI 1080
HKAYKDKNKY RFEIMGEEEI AFKMIRTNVS HVVGQLDDIR KNPRKFVCLN DNIDHNHKDA 1140
RTVKAVLRDF YESMFPIPSQ FELPREYRNR FLHMHELQEW RAYRDKLKFW THCVLATLII 1200
FTIFSFFAEQ IIALKRKIFP RRRIHKEASP DRIRV 1235 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:InterPro. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0003976; F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; IEA:EC. GO:0046835; P:carbohydrate phosphorylation; IMP:MGI. GO:0030154; P:cell differentiation; IEA:InterPro. GO:0009306; P:protein secretion; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |