CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin beta-like protein 3 
Protein Synonyms/Alias
  
Gene Name
 TBL3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13GSVTRLWKAIHTAPVubiquitination[1]
236ARSLRLQKQFAGYSEubiquitination[1, 2, 3, 4, 5]
322KAGQVMLKESFLVTGubiquitination[1]
342VKLWPLPKALLSKNTubiquitination[2, 5]
347LPKALLSKNTAPDNGubiquitination[1, 3, 4, 5, 6]
381VAIAPNDKLLATGSQubiquitination[1, 3, 4]
393GSQDRTAKLWALPQCubiquitination[1]
446LQDFSCLKTFEGHDAubiquitination[6]
477SGSDGLVKLWTIKNNubiquitination[1, 4]
482LVKLWTIKNNECVRTubiquitination[1, 5]
496TLDAHEDKVWGLHCSacetylation[5]
496TLDAHEDKVWGLHCSubiquitination[1]
522DSRVILWKDVTEAEQubiquitination[1, 3, 4, 5, 6]
553LDNLLHEKRYLRALGubiquitination[1, 3, 5]
587RDPEACEKLEATMLRacetylation[5]
587RDPEACEKLEATMLRubiquitination[1, 5, 6]
600LRLRRDQKEALLRFCubiquitination[3]
693PTPWETHKGALP***ubiquitination[1, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
XAWQEGSVTR LWKAIHTAPV ATMAFDPTST LLATGGCDGA VRVWDIVRHY GTHHFRGSPG 60
VVHLVAFHPD PTRLLLFSSA TDAAIRVWSL QDRSCLAVLT AHYSAVTSLA FSADGHTMLS 120
SGRDKICIIW DLQSCQATRT VPVFESVEAA VLLPEEPVSQ LGVKSPGLYF LTAGDQGTLR 180
VWEAASGQCV YTQAQPPGPG QELTHCTLAH TAGVVLTATA DHNLLLYEAR SLRLQKQFAG 240
YSEEVLDVRF LGPEDSHVVV ASNSPCLKVF ELQTSACQIL HGHTDIVLAL DVFRKGWLFA 300
SCAKDQSVRI WRMNKAGQVM LKESFLVTGS QDCTVKLWPL PKALLSKNTA PDNGPILLQA 360
QTTQRCHDKD INSVAIAPND KLLATGSQDR TAKLWALPQC QLLGVFSGHR RGLWCVQFSP 420
MDQVLATASA DGTIKLWALQ DFSCLKTFEG HDASVLKVAF VSRGTQLLSS GSDGLVKLWT 480
IKNNECVRTL DAHEDKVWGL HCSRLDDHAL TGASDSRVIL WKDVTEAEQA EEQARQEEQV 540
VRQQELDNLL HEKRYLRALG LAISLDRPHT VLTVIQAIRR DPEACEKLEA TMLRLRRDQK 600
EALLRFCVTW NTNSRHCHEA QAVLGVLLRR EAPEELLAYE GVRAALEALL PYTERHFQRL 660
SRTLQAAAFL DFLWHNMKLP VPAAAPTPWE THKGALP 697 
Gene Ontology
 GO:0032040; C:small-subunit processome; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:InterPro. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR013934; SSU_processome_Utp13.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08625; Utp13
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.