UniProt Accession

 B2RTM0_MOUSE; B2RTM0 

Genbank Protein ID

 BC139425; BC139437; CH466572; CH466572; CH466561; CH466561; CH466561; CH466561; CH466561; CH466561; CH466561; CH466561; CH466620 

Genbank Nucleotide ID

 AAI39426.1; AAI39438.1; EDL10567.1; EDL10574.1; EDL32537.1; EDL32545.1; EDL32551.1; EDL32558.1; EDL32563.1; EDL32608.1; EDL32622.1; EDL32632.1; EDL38881.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 Gm11275 

Gene Synonyms/Alias

 Hist2h4; OTTMUSG00000000446; mCG_1027097; mCG_1044802; mCG_121063; mCG_142242; mCG_23033; mCG_23039; mCG_49272; mCG_49679; mCG_7726; mCG_7729; mCG_7731 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	DNIQGITKPAIRRLA	ubiquitination	[1]
92	MDVVYALKRQGRTLY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.