| Tag | Content |
|---|
| CPLM ID | CPLM-011229 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 3 |
Protein Synonyms/Alias | Enhancer of split groucho-like protein 3; ESG3 |
Gene Name | TLE3 |
Gene Synonyms/Alias | KIAA1547 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 343 | GLRSMPGKPPGMDPI | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Sequence Annotation | REPEAT 484 522 WD 1.
REPEAT 530 569 WD 2.
REPEAT 574 613 WD 3.
REPEAT 616 655 WD 4.
REPEAT 657 696 WD 5.
REPEAT 698 737 WD 6.
REPEAT 739 771 WD 7.
REGION 199 268 CCN domain.
MOTIF 225 228 Nuclear localization signal (Potential).
MOD_RES 203 203 Phosphoserine.
MOD_RES 207 207 Phosphoserine.
MOD_RES 217 217 Phosphoserine.
MOD_RES 240 240 Phosphoserine.
MOD_RES 245 245 Phosphoserine.
MOD_RES 259 259 Phosphothreonine.
MOD_RES 263 263 Phosphoserine.
MOD_RES 267 267 Phosphoserine.
MOD_RES 286 286 Phosphoserine.
MOD_RES 312 312 Phosphothreonine.
MOD_RES 317 317 Phosphoserine.
MOD_RES 319 319 Phosphothreonine.
MOD_RES 321 321 Phosphothreonine.
MOD_RES 328 328 Phosphothreonine.
MOD_RES 334 334 Phosphothreonine.
MOD_RES 413 413 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 772 AA |
Protein Sequence | MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 180
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 360
TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVGFDPHPP 420
MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 480
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 540
VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ 600
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 660
PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 720
TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY 764 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0007219; P:Notch signaling pathway; TAS:Reactome. GO:0009887; P:organ morphogenesis; TAS:ProtInc. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |