UniProt Accession

 TAF9B_HUMAN; Q9HBM6; B2RUZ9; Q9Y2S3 

Genbank Protein ID

 AF077053; AF220509; AL049589; CH471104; BC009566; BC010350; BC071649; BC146952; BC146960 

Genbank Nucleotide ID

 AAD27786.1; AAG09711.1; CAI42952.1; EAW98601.1; AAH09566.1; AAH10350.1; AAH71649.1; AAI46953.1; AAI46961.1 

Protein Name

 Transcription initiation factor TFIID subunit 9B 

Protein Synonyms/Alias

 Neuronal cell death-related protein 7; DN-7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L 

Gene Name

 TAF9B 

Gene Synonyms/Alias

 TAF9L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MESGKMAPPKNA	ubiquitination	[1, 2]
10	SGKMAPPKNAPRDAL	ubiquitination	[2]
24	LVMAQILKDMGITEY	ubiquitination	[2, 3]
62	KIYSSHAKKPNVDAD	ubiquitination	[2]
63	IYSSHAKKPNVDADD	ubiquitination	[2]
99	LLDIARQKNQTPLPL	ubiquitination	[2]
108	QTPLPLIKPYAGPRL	acetylation	[4]
108	QTPLPLIKPYAGPRL	ubiquitination	[2, 5]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. 

Sequence Annotation

 MOD_RES 156 156 Phosphothreonine (By similarity).
 MOD_RES 159 159 Phosphothreonine.
 MOD_RES 174 174 Phosphothreonine.
 MOD_RES 177 177 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
 GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IC:BHF-UCL.
 GO:0006352; P:DNA-dependent transcription, initiation; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
 GO:0012501; P:programmed cell death; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara. 

Interpro

 IPR009072; Histone-fold.
 IPR003162; TFIID-31. 

Pfam

 PF02291; TFIID-31kDa 

SMART

  

PROSITE

  

PRINTS