UniProt Accession

 AQP4_RAT; P47863 

Genbank Protein ID

 U14007; AF144082; L27588 

Genbank Nucleotide ID

 AAC52152.1; AAD37965.1; AAA17730.1 

Protein Name

 Aquaporin-4 

Protein Synonyms/Alias

 AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 

Gene Name

 Aqp4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
263	VELKRRLKEAFSKAA	acetylation	[1]
268	RLKEAFSKAAQQTKG	acetylation	[1]
268	RLKEAFSKAAQQTKG	ubiquitination	[2]
274	SKAAQQTKGSYMEVE	ubiquitination	[2]
295	ETEDLILKPGVVHVI	acetylation	[1]
313	RGDEKKGKDSSGEVL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity. 

Sequence Annotation

 MOTIF 97 99 NPA 1.
 MOTIF 213 215 NPA 2.
 MOD_RES 111 111 Phosphoserine; by PKG.
 MOD_RES 180 180 Phosphoserine; by PKC.
 MOD_RES 285 285 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.
 CARBOHYD 153 153 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0030315; C:T-tubule; IDA:RGD.
 GO:0015288; F:porin activity; IDA:RGD.
 GO:0015250; F:water channel activity; IDA:RGD.
 GO:0015670; P:carbon dioxide transport; IDA:UniProtKB.
 GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD.
 GO:0071346; P:cellular response to interferon-gamma; IEA:Compara.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0042538; P:hyperosmotic salinity response; IEP:RGD.
 GO:0051260; P:protein homooligomerization; IDA:RGD.
 GO:0070295; P:renal water absorption; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0009314; P:response to radiation; IEP:RGD.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 

Interpro

 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR00783; MINTRINSICP.