CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-tubulin complex component 2 
Protein Synonyms/Alias
 GCP-2 
Gene Name
 TUBGCP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 
NCBI Taxa ID
 9601 
Lysine Modification
Position
Peptide
Type
References
426IQEDYNDKYWDQRYTubiquitination[1]
455DKILSTGKYLNVVREubiquitination[2, 3]
473DVTCPVAKEIIYTLKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (By similarity). 
Sequence Annotation
 MOD_RES 83 83 Phosphotyrosine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 902 AA 
Protein Sequence
MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK VKIAEFSRTP 60
EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ NAKERAELAA AAVGSSTTSV 120
NVPAAASKIS MQELEELRKQ LGSVATGSTL QQSLELKRKM LRDKQNKKNS DQHLPIFPAW 180
VYERPALIGD FLIGAGISTD TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVTAQPLAG 240
RQSRTFLVDP NLDLSIRELV NRILPVAASY STVTRFIEEK SSFEYGQVNH ALAAAMRTLV 300
KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC LGGSTLSLLH 360
DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII HDPYSEFMVE EHELRKERIQ 420
EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI LSTGKYLNVV RECGHDVTCP VAKEIIYTLK 480
ERAYVEQIEK AFNYASKVLL DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR 540
KPVEDITPPR LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM 600
AHADPTELTL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH VERQLCSVWI 660
SNKTAKQHSL PSAQWFAGAF TLRQRMLNFV QNIQYYMMFE VMEPTWHILE KNLKSASNID 720
DVLGYHTGFL DTCLKDCMLT NPELLKVFSK LMSVCVMFTN CMQKFTQSMK LDGELGGQTL 780
EHGTLPGLPA GAEDRARKEL ARKHLAEHAD AAQLVSGFEA TINKFDKNFS AHLLDLLARL 840
SIYSTSDCEH GMASVTSRLD FNGFYTERLE RLSAERSQKA APQVPVLRGP PAPAPRVAVT 900
AQ 902 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:InterPro.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR007259; Spc97_Spc98. 
Pfam
 PF04130; Spc97_Spc98 
SMART
  
PROSITE
  
PRINTS