UniProt Accession

 HA1K_MOUSE; P04223; O19459; Q31165; Q31192; Q95458 

Genbank Protein ID

 X01652; M18525; U47330; M18964; M11975; M34932 

Genbank Nucleotide ID

 CAA25816.1; AAA53202.1; AAB17608.1; AAA39568.1; AAA39654.1; AAA39596.1 

Protein Name

 H-2 class I histocompatibility antigen, K-K alpha chain 

Protein Synonyms/Alias

 H-2K(K) 

Gene Name

 H2-K1 

Gene Synonyms/Alias

 H2-K 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
338	RRRNTGGKGGDYALA	ubiquitination	[1]

Reference

 [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 206 294 Ig-like C1-type.
 REGION 22 111 Alpha-1.
 REGION 112 203 Alpha-2.
 REGION 204 295 Alpha-3.
 REGION 296 305 Connecting peptide.
 MOD_RES 354 354 Phosphoserine (By similarity).
 CARBOHYD 107 107 N-linked (GlcNAc...).
 CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
 DISULFID 122 185 By similarity.
 DISULFID 224 280 By similarity.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0042605; F:peptide antigen binding; IDA:MGI.
 GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
 GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI.
 GO:0042742; P:defense response to bacterium; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.