CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 
Protein Synonyms/Alias
 GroEL protein; Protein Cpn60; Stress protein H5 
Gene Name
 groL 
Gene Synonyms/Alias
 groEL; mopA; BSU06030 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
135ENLKEISKPIEGKESacetylation[1]
325ASKVVVTKENTTIVEacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MAKEIKFSEE ARRAMLRGVD ALADAVKVTL GPKGRNVVLE KKFGSPLITN DGVTIAKEIE 60
LEDAFENMGA KLVAEVASKT NDVAGDGTTT ATVLAQAMIR EGLKNVTAGA NPVGVRKGME 120
QAVAVAIENL KEISKPIEGK ESIAQVAAIS AADEEVGSLI AEAMERVGND GVITIEESKG 180
FTTELEVVEG MQFDRGYASP YMVTDSDKME AVLDNPYILI TDKKITNIQE ILPVLEQVVQ 240
QGKPLLLIAE DVEGEALATL VVNKLRGTFN AVAVKAPGFG DRRKAMLEDI AVLTGGEVIT 300
EDLGLDLKST QIAQLGRASK VVVTKENTTI VEGAGETDKI SARVTQIRAQ VEETTSEFDR 360
EKLQERLAKL AGGVAVIKVG AATETELKER KLRIEDALNS TRAAVEEGIV SGGGTALVNV 420
YNKVAAVEAE GDAQTGINIV LRALEEPIRQ IAHNAGLEGS VIVERLKNEE IGVGFNAATG 480
EWVNMIEKGI VDPTKVTRSA LQNAASVAAM FLTTEAVVAD KPEENGGGAG MPDMGGMGGM 540
GGMM 544 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.