CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042900
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone deacetylase 9 
Protein Synonyms/Alias
  
Gene Name
 HDAC7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51CECLRGRKASLEELQubiquitination[1]
83RLKLDNGKLAGLLAQacetylation[2, 3]
83RLKLDNGKLAGLLAQubiquitination[1, 4]
325AVIRVHSKYWGCMQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 384 AA 
Protein Sequence
XLIYDSVMLK HQCSCGDNSR HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV 60
HSERHVLLYG TNPLSRLKLD NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW 120
AAGSVTDLAF KVASRELKDV HHGNGTQQTF YQDPSVLYIS LHRHDDGNFF PGSGAVDEVG 180
AGSGEGFNVN VAWAGGLDPP MGDPEYLAAF RIVVMPIARE FSPDLVLVSA GFDAAEGHPA 240
PLGGYHVSAK CFGYMTQQLM NLAGGAVVLA LEGGHDLTAI CDASEACVAA LLGNRVDPLS 300
EEGWKQKPNL NAIRSLEAVI RVHSKYWGCM QRLASCPDSW VPRVPGADKE EVEAVTALAS 360
LSVGILAEDR PSEQLVEEEE PMNL 384 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS