UniProt Accession

 SH3K1_HUMAN; Q96B97; B7Z1D5; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96RN4; Q9NYR0 

Genbank Protein ID

 AF230904; AF542051; AK293234; AK293237; AL732423; AL732325; AL732327; AL732423; AL732327; AL732327; AL732325; AL732423; AL732327; AL732423; AL732325; AL732327; AL732423; AL732409; AL772197; BC015806; BC050663; AF329267; AF329268 

Genbank Nucleotide ID

 AAF37854.1; AAN77231.1; BAH11470.1; BAH11471.1; CAI40277.1; CAI40277.1; CAI40277.1; CAI40278.1; CAI40278.1; CAI40511.1; CAI40511.1; CAI40511.1; CAI40512.1; CAI40512.1; CAI41254.1; CAI41254.1; CAI41254.1; AAH15806.1; AAH50663.1; AAK95587.1; AAO13348.1 

Protein Name

 SH3 domain-containing kinase-binding protein 1 

Protein Synonyms/Alias

 CD2-binding protein 3; CD2BP3; Cbl-interacting protein of 85 kDa; Human Src family kinase-binding protein 1; HSB-1 

Gene Name

 SH3KBP1 

Gene Synonyms/Alias

 CIN85 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
598	FGTEGKPKMEPAASS	sumoylation	[1]

Reference

 [1] CD2AP regulates SUMOylation of CIN85 in podocytes.
 Tossidou I, Niedenthal R, Klaus M, Teng B, Worthmann K, King BL, Peterson KJ, Haller H, Schiffer M.
 Mol Cell Biol. 2012 Mar;32(6):1068-79. [PMID: 22203040] 

Functional Description

 Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. 

Sequence Annotation

 DOMAIN 1 58 SH3 1.
 DOMAIN 98 157 SH3 2.
 DOMAIN 267 328 SH3 3.
 MOD_RES 156 156 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 254 254 Phosphothreonine.
 MOD_RES 436 436 Phosphoserine.
 MOD_RES 468 468 Phosphoserine (By similarity).
 MOD_RES 509 509 Phosphoserine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 521 521 Phosphoserine.
 MOD_RES 587 587 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain; SH3-binding; Synapse; Synaptosome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 665 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008360; P:regulation of cell shape; IMP:UniProtKB. 

Interpro

 IPR000108; p67phox.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00018; SH3_1
 PF07653; SH3_2 

SMART

 SM00326; SH3 

PROSITE

 PS50002; SH3 

PRINTS

 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.