UniProt Accession

 C42S1_HUMAN; Q9NRR8; D3DV12; Q9HB17; Q9NQR2 

Genbank Protein ID

 AF187845; AF286592; AL590133; CH471121; CH471121; CH471121; BC012796; BC041604; AF286041 

Genbank Nucleotide ID

 AAF87597.1; AAG17723.1; CAI13349.1; EAW53477.1; EAW53478.1; EAW53479.1; AAH12796.2; AAH41604.1; AAF97248.1 

Protein Name

 CDC42 small effector protein 1 

Protein Synonyms/Alias

 CDC42-binding protein SCIP1; Small effector of CDC42 protein 1 

Gene Name

 CDC42SE1 

Gene Synonyms/Alias

 SPEC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	LGCCVVEKPQPKKKR	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. 

Sequence Annotation

 DOMAIN 30 43 CRIB.
 REGION 19 24 Mediates phosphoinositide-binding.
 LIPID 10 10 S-palmitoyl cysteine (Probable).
 LIPID 11 11 S-palmitoyl cysteine (Probable).  

Keyword

 Alternative splicing; Cell membrane; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane; Palmitate; Phagocytosis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 79 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR000095; PAK_box_Rho-bd. 

Pfam

  

SMART

  

PROSITE

 PS50108; CRIB 

PRINTS