CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Monoacylglycerol lipase ABHD6 
Protein Synonyms/Alias
 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6 
Gene Name
 Abhd6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
126LSIVGQVKRIHQFVEubiquitination[1]
189NPFVQRLKELEESAAubiquitination[1]
223LCSYVRFKVPQQILQubiquitination[1]
245PHNSFYRKLFLEIVNubiquitination[1]
254FLEIVNEKSRYSLHEubiquitination[1]
267HENMDKIKVPTQIIWubiquitination[1]
276PTQIIWGKQDQVLDVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. 
Sequence Annotation
 ACT_SITE 148 148 Charge relay system (By similarity).
 ACT_SITE 278 278 Charge relay system (By similarity).
 ACT_SITE 306 306 Charge relay system (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Hydrolase; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYAHHEDYQF 60
CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS 120
IVGQVKRIHQ FVECLKLNKK PFHLIGTSMG GHVAGVYAAY YPSDVCSLSL VCPAGLQYST 180
DNPFVQRLKE LEESAAIQKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN 240
SFYRKLFLEI VNEKSRYSLH ENMDKIKVPT QIIWGKQDQV LDVSGADILA KSISNSQVEV 300
LENCGHSVVM ERPRKTAKLI VDFLASVHNT DNKKLN 336 
Gene Ontology
 GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0047372; F:acylglycerol lipase activity; IDA:MGI.
 GO:0060292; P:long term synaptic depression; IMP:MGI.
 GO:0030336; P:negative regulation of cell migration; IMP:MGI.
 GO:2000124; P:regulation of endocannabinoid signaling pathway; IMP:MGI. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00111; ABHYDROLASE.
 PR00412; EPOXHYDRLASE.