CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013034
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase LMTK2 
Protein Synonyms/Alias
 Brain-enriched kinase; Lemur tyrosine kinase 2 
Gene Name
 Lmtk2 
Gene Synonyms/Alias
 Brek; Kiaa1079 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
176LKVSASPKEQDTFLKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Phosphorylates PPP1C, phosphorylase b and CFTR (By similarity). 
Sequence Annotation
 DOMAIN 136 406 Protein kinase.
 NP_BIND 142 150 ATP (By similarity).
 ACT_SITE 264 264 Proton acceptor (By similarity).
 BINDING 167 167 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1471 AA 
Protein Sequence
MPGPPASPPP PMLLLLLLLT VGCARAAPLP QTGAGEVPVV EVPSLFVILS VCSLLILIVL 60
IANCVSCCKD PEIDFKEFED NFDDEIDFTP PAEDTPSIQS PAEVFTLSVP NISLPAPSQF 120
QASVEGLKSQ VARHSLNYIQ EIGSGWFGKV LLGETYTGTS VARVIVKELK VSASPKEQDT 180
FLKSGEPYYI LQHPNVLQCV GQCVEAIPYL LVFEFCDLGD LKAYLHNEQE HVRGDSQTML 240
LQRMACEIAA GLAAMHKLHF LHSDLALRNC YLTSDLNVKV GDYGIGFSRY KEDYIETDDK 300
KVFPLRWTAP ELVTSFQDRL LTADQTKYSN IWSLGVTLWE LFNNAAQPYA NLSDLDVLNQ 360
VIRERDMKLP KPQLEQPYSD RWYEVLQFCW LPPDKRPAAE DVHRLLTYLR MQSQRDSEVD 420
FEQQWTALKP DTNSRDASSS AAFPILDHFA RDRLGREMEE VLTVTETSQG LSFEYVWEAA 480
KHDHFDEQGR GHPDEALSYS SMFFPVEVFE NSLSDPGPGK QDDSGQEVPV RAPGVVPVFD 540
AHNLSVGSDY YIQLEEKSSS NLGLDPPALL TTEVDKLERA GAEEPRTEED FFQSSAHPKE 600
ASSTEDSRAT SIPGSPFNLF SDLDKADDLP SHQKIFDLME LNGVQADFKP AILSSSLDDP 660
KDTCQSDKEK PHKLLDQGPL CLSESLLHQD HFDPLSVQEL SENFLFLQEK NLLKGSLTTK 720
EQVSDLQTEL KNAGFTSALL ESPQRGSESS ELEFLENTLD FPLSQGDTRG QNEGAGVRRH 780
SGTSPQASPA LLTEEGSPTA PTDPILKPEE TKSFRDVRVP EDSICLELGP DPVTVGVEIP 840
ATDAKTLDGG NRPPDVTCQS KEALSLTNRH PILVNDITAQ GSVESCLPES RQDLQNEPFS 900
EDPLSVSSLE KHSEAAETLN QLNSKAAPED AALASALSSD STSQDSLLED SLSTPIPTSE 960
QSVETPDSLD SVDVREALLE SLGSHTPRKL LPPDKPADSG YETENLESPE WTLHPAPEGT 1020
ADSDAAAAGD SGHSSLPPNP VIVISDAGDG HRGAEGPPQS FTLGPQSSYR DSAYFSDNDS 1080
EPDKKPEEVP GTSANALVLV KGQSPPESVV PEESSDVREG CLEAPQDKPD QSRVSTLQNS 1140
CHSELQETLQ PTPADASRES CPVNDEASSP LSLLNSEPSS CDDLDTQEDR PCTLASTGTN 1200
TNELLAYMSS TLDKSLPSHL ESSKLKEPDI EGKYLGKLCV SGMLDLSEDG MDADEEDENS 1260
DDSDEDLRAF NLHSLSSESE DDTEHPVPII VSNDDGRHLR SLLKPSAAEA IEQLPEDWKK 1320
EKKAVTFFDD VTVYLFDQET PTKELGHCGG EAHGPGPSSP AASSSSPYLG RCMNSESSTD 1380
EEGGGFEWDD DFSPDPFMSK TTSLLGSKPS LQTSKYFSPP PPARSAEQSW PHVSPCSRFS 1440
ISPANIASFS LTHLTDSDIE QGGSSEDGDK D 1471 
Gene Ontology
 GO:0005737; C:cytoplasm; ISA:MGI.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; ISA:MGI.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
 GO:0007411; P:axon guidance; ISA:MGI.
 GO:0045022; P:early endosome to late endosome transport; IEA:Compara.
 GO:0032456; P:endocytic recycling; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISA:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; ISA:MGI.
 GO:0001881; P:receptor recycling; IEA:Compara.
 GO:0033572; P:transferrin transport; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.