CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018570
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate lyase 
Protein Synonyms/Alias
 ASAL; Arginosuccinase 
Gene Name
 Asl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
51AYSRGLEKAGLLTKAacetylation[1]
80EWAQGTFKLHPNDEDacetylation[1]
131WMRQTCSKLSALLRVacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 288 288 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Lyase; Reference proteome; Urea cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MASESGKLWG GRFVGAVDPI MEKFNSSISY DRHLWNVDVQ GSKAYSRGLE KAGLLTKAEM 60
QQILQGLDKV AEEWAQGTFK LHPNDEDIHT ANERRLKELI GEAAGKLHTG RSRNDQVVTD 120
LRLWMRQTCS KLSALLRVLI GTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL 180
TRDSERLLEV QKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA 240
EFLFWASLCM THLSRMAEDL ILYGTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA 300
GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMI AVLQVATGVI STLQIHRENM 360
KQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNLLSL QELQTISPLF 420
SGDVSHVWDY SHSVEQYSAL GGTAKSSVEW QIRQVRALLQ AQEP 464 
Gene Ontology
 GO:0004056; F:argininosuccinate lyase activity; IEA:EC.
 GO:0019676; P:ammonia assimilation cycle; IMP:MGI.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
 GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway. 
Interpro
 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.