| Tag | Content |
|---|
| CPLM ID | CPLM-014930 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 2 |
Protein Synonyms/Alias | ELP2; SHINC-2; STAT3-interacting protein 1; StIP1 |
Gene Name | ELP2 |
Gene Synonyms/Alias | STATIP1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 215 | RIWKLYIKSTSLETQ | ubiquitination | [1] | | 230 | DDDNIRLKENTFTIE | ubiquitination | [1] | | 389 | FVSGADEKVLRVFSA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Regulates the ligand-dependent activation of STAT3 (By similarity). |
Sequence Annotation | REPEAT 13 53 WD 1.
REPEAT 56 100 WD 2.
REPEAT 105 152 WD 3.
REPEAT 158 200 WD 4.
REPEAT 205 246 WD 5.
REPEAT 281 329 WD 6.
REPEAT 339 378 WD 7.
REPEAT 386 425 WD 8.
REPEAT 436 474 WD 9.
REPEAT 565 609 WD 10.
REPEAT 612 651 WD 11.
REPEAT 667 706 WD 12.
REPEAT 712 753 WD 13.
REPEAT 777 826 WD 14. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 826 AA |
Protein Sequence | MVAPVLETSH VFCCPNRVRG VLNWSSGPRG LLAFGTSCSV VLYDPLKRVV VTNLNGHTAR 60
VNCIQWICKQ DGSPSTELVS GGSDNQVIHW EIEDNQLLKA VHLQGHEGPV YAVHAVYQRR 120
TSDPALCTLI VSAAADSAVR LWSKKGPEVP ILACGNDDCR IHIFAQQNDQ FQKVLSLCGH 180
EDWIRGVEWA AFGRDLFLAS CSQDCLIRIW KLYIKSTSLE TQDDDNIRLK ENTFTIENES 240
VKIAFAVTLE TVLAGHENWV NAVHWQPVFY KDGVLQQPVR LLSASMDKTM ILWAPDEESG 300
VWLEQREWTP EIVISGHFDG VQDLVWDPEG EFIITVGTDQ TTRLFAPWKR KDQSQVTWHE 360
IARPQIHGYD LKCLAMINRF QFVSGADEKV LRVFSAPRNF VENFCAITGQ SLNHVLCNQD 420
SDLPEGATVP ALGLSNKAVF QGDIASQPSD EEELLTSTGF EYQQVAFQPS ILTEPPTEDH 480
LLQNTLWPEV QKLYGHGYEI FCVTCNSSKT LLASACKAAK KEHAAIILWN TTSWKQVQNL 540
VFHSLTVTQM AFSPNEKFLL AVSRDRTWSL WKKQDTISPE FEPVFSLFAF TNKITSVHSR 600
IIWSCDWSPD SKYFFTGSRD KKVVVWGECD STDDCIEHNI GPCSSVLDVG GAVTAVSVCP 660
VLHPSQRYVV AVGLECGKIC LYTWKKTDQV PEINDWTHCV ETSQSQSHTL AIRKLCWKNC 720
SGKTEQKEAE GAEWLHFASC GEDHTVKIHR VNKCAL 756 |
Gene Ontology | GO:0005737; C:cytoplasm; NAS:HGNC. GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IC:HGNC. GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB. GO:0005730; C:nucleolus; IC:HGNC. GO:0008023; C:transcription elongation factor complex; IDA:HGNC. GO:0046425; P:regulation of JAK-STAT cascade; IEA:Compara. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:HGNC. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |