CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plectin 
Protein Synonyms/Alias
  
Gene Name
 PLEC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
293DVPQPDEKSIITYVSubiquitination[1]
369WSQFLKFKEMELPAKacetylation[2]
376KEMELPAKEADKNRSubiquitination[3]
384EADKNRSKGIYQSLEubiquitination[1, 3]
400AVQAGQLKVPPGYHPubiquitination[1, 3]
488EVERDLDKADSMIRLacetylation[2]
488EVERDLDKADSMIRLubiquitination[3]
504FNDVQTLKDGRHPQGubiquitination[1, 3]
537TEYNLRLKAGVAAPAubiquitination[1, 3]
647RLDLQYAKLLNSSKAacetylation[2]
647RLDLQYAKLLNSSKAubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 703 AA 
Protein Sequence
MSGEDAEVRA VSEDVSNGSS GSPSPGDTLP WNLGKTQRSR RSGGGAGSNG SVLDPAERAV 60
IRIADERDRV QKKTFTKWVN KHLIKHWRAE AQRHISDLYE DLRDGHNLIS LLEVLSGDSL 120
PRERDVSRSS RLPREKGRMR FHKLQNVQIA LDYLRHRQVK LVNIRNDDIA DGNPKLTLGL 180
IWTIILHFQI SDIQVSGQSE DMTAKEKLLL WSQRMVEGYQ GLRCDNFTSS WRDGRLFNAI 240
IHRHKPLLID MNKVYRQTNL ENLDQAFSVA ERDLGVTRLL DPEDVDVPQP DEKSIITYVS 300
SLYDAMPRVP DVQDGVRANE LQLRWQEYRE LVLLLLQWMR HHTAAFEERR FPSSFEEIEI 360
LWSQFLKFKE MELPAKEADK NRSKGIYQSL EGAVQAGQLK VPPGYHPLDV EKEWGKLHVA 420
ILEREKQLRS EFERLECLQR IVTKLQMEAG LCEEQLNQAD ALLQSDVRLL AAGKVPQRAG 480
EVERDLDKAD SMIRLLFNDV QTLKDGRHPQ GEQMYRRVYR LHERLVAIRT EYNLRLKAGV 540
AAPATQVAQV TLQSVQRRPE LEDSTLRYLQ DLLAWVEENQ HRVDGAEWGV DLPSVEAQLG 600
SHRGLHQSIE EFRAKIERAR SDEGQLSPAT RGAYRDCLGR LDLQYAKLLN SSKARLRSLE 660
SLHSFVAAAT KELMWLNEKE EEEVGFDWSD RNTNMTAKKE SYS 703 
Gene Ontology
  
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00307; CH 
SMART
 SM00033; CH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS