CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005968
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein Hox-A13 
Protein Synonyms/Alias
 Homeobox protein Hox-1J 
Gene Name
 HOXA13 
Gene Synonyms/Alias
 HOX1J 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
303AQPPHLWKSTLPDVVubiquitination[1, 2]
335PYTKVQLKELEREYAubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior- posterior axis. 
Sequence Annotation
 DNA_BIND 322 381 Homeobox.  
Keyword
 3D-structure; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA AGAGGGGFPH 60
PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG AASAYSSAPG EAPPSAAAAA 120
AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP 180
CARMGPHPNA IKSCAQPASA AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY 240
HHHQPMPGYL DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH 300
LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD KRRRISATTN 360
LSERQVTIWF QNRRVKEKKV INKLKTTS 388 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0048844; P:artery morphogenesis; IEA:Compara.
 GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0060847; P:endothelial cell fate specification; IEA:Compara.
 GO:0001886; P:endothelial cell morphogenesis; IEA:Compara.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045840; P:positive regulation of mitosis; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030510; P:regulation of BMP signaling pathway; IEA:Compara.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0001894; P:tissue homeostasis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0003281; P:ventricular septum development; IEA:Compara. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR022067; HoxA13_N. 
Pfam
 PF00046; Homeobox
 PF12284; HoxA13_N 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS